Early MR Lymphography with Gadofluorine M in Rabbits
| Autor: | Bernd Misselwitz, Hanns-Joachim Weinmann, Johannes Platzek |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Iliac Lymph Node Gadolinium Contrast Media chemistry.chemical_element Groin Mr lymphography Organometallic Compounds medicine Animals Radiology Nuclear Medicine and imaging Lymph node medicine.diagnostic_test business.industry Gadofluorine M Magnetic resonance imaging Neoplasms Experimental Magnetic Resonance Imaging Hindlimb medicine.anatomical_structure Lymphatic system chemistry Lymphatic Metastasis Injections Intravenous Female Lymph Nodes Rabbits Lymph Radiology business Nuclear medicine |
| Zdroj: | Radiology. 231:682-688 |
| ISSN: | 1527-1315 0033-8419 |
| Popis: | To investigate the dose and time dependency of gadofluorine M for lymph node imaging and the detection of lymph node metastases in an animal model and to compare gadofluorine M with Gadomer (both, Schering, Berlin, Germany) for lymph node enhancement.Enhancement of popliteal and iliac lymph nodes was studied in VX2 tumor-bearing rabbits before injection and at 5-120 minutes and 24 hours after intravenous bolus injection of 0.025, 0.05, and 0.1 mmol gadolinium per kilogram of body weight gadofluorine M (six rabbits) or 0.5 mmol/kg Gadomer (eight rabbits). Effects of treatment and time point at enhancement were evaluated with repeated measures analysis of variance. Means were separated with all-pairs comparison with Tukey-Kramer adjustment. After 1.5-T magnetic resonance (MR) imaging, lymph nodes were removed, and prepared sections were stained with hematoxylin-eosin for microscopic examination.MR images in VX2 tumor-bearing rabbits revealed rapid and strong signal intensity increase in the functional lymph node tissue by 15 minutes after intravenous injection of gadofluorine M. Maximum enhancement of 165%-309% was observed 60-90 minutes after injection (enhancement with 0.05 and 0.1 mmol/kg significantly different from that with 0.025 mmol/kg, Por =.05). Metastatic tissue showed only slight enhancement at early time points, resulting in high-contrast differentiation between functional and metastatic tissue. Intravenous injection of the blood-pool agent Gadomer induced only short and inhomogeneous lymph node enhancement (enhancement significantly lower [Por =.05] than that with gadofluorine M).Findings in the study showed that gadofluorine M produces rapid lymph node accumulation. Diagnosis of lymph node metastases was shown with intravenous injection of gadofluorine M with a minimum effective diagnostic dose of 0.025 mmol/kg. |
| Databáze: | OpenAIRE |
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