An Open Study of Procaine Penicillin G, Clavulanate-Potentiated Amoxycillin and Probenecid in the Treatment of Acute Gonorrhoea
| Autor: | P D Ekwere |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class Antibiotics Administration Oral Penicillin G Procaine Microbial Sensitivity Tests Amoxicillin-Potassium Clavulanate Combination urologic and male genital diseases Injections Intramuscular Biochemistry Gastroenterology Clavulanic Acids Gonorrhea Internal medicine parasitic diseases medicine Humans Dysuria Urethritis Antibacterial agent Amoxicillin/clavulanic acid Probenecid business.industry Biochemistry (medical) Amoxicillin Cell Biology General Medicine medicine.disease Neisseria gonorrhoeae Anti-Bacterial Agents Surgery Acute Disease Drug Therapy Combination Female medicine.symptom business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of International Medical Research. 22:236-243 |
| ISSN: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006059402200405 |
| Popis: | In an open study 55 patients presenting with acute gonorrhoea were given 4.8 mega units procaine penicillin G, intramuscularly, and oral probenecid (1 g) plus one 375-mg tablet clavulanate-potentiated amoxycillin orally. Before this treatment, 53 patients (96.4%) had presented with a purulent discharge, and dysuria was present in 47 patients (85.5%). The presence of Neisseria gonorrhoeae was confirmed by bacterial culture in 54 patients (98.2%). The majority of pathogens (92.5%) were penicillin resistant. On day 3 after treatment, dysuria was absent in 53 patients (96.4%) and there was no discharge in 40 cases (72.7%). N. gonorrhoeae was eradicated in 53 patients (96.4%). Two further patients were bacteriologically cured, but were suffering from post-gonococcal urethritis. The patients in whom discharge was still apparent were further assessed on day 7; discharge was resolved or resolving in all but one patient. There was one treatment failure. No adverse reactions were reported. |
| Databáze: | OpenAIRE |
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