Airway exposure to TiO2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice
| Autor: | Anna Jacobsen Lauvas, Ulla Vogel, Marie Sønnegaard Poulsen, Sandra Goericke-Pesch, Astrid Skovmand, Martin Roursgaard, Karin Sørig Hougaard, Zdenka O. Kyjovska |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Neutrophil granulocyte
media_common.quotation_subject Inflammation 010501 environmental sciences Toxicology 01 natural sciences Andrology 03 medical and health sciences Oral administration medicine Airways Testosterone 030304 developmental biology 0105 earth and related environmental sciences media_common 0303 health sciences business.industry Reproduction technology industry and agriculture Epididymis Sperm medicine.anatomical_structure Titanium dioxide medicine.symptom Airway business Intratracheal instillation |
| Zdroj: | Lauvås, A J, Skovmand, A, Poulsen, M S, Kyjovska, Z O, Roursgaard, M, Goericke-Pesch, S, Vogel, U B & Hougaard, K S 2019, ' Airway exposure to TiO 2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice ', Reproductive Toxicology, vol. 90, pp. 134-140 . https://doi.org/10.1016/j.reprotox.2019.07.023 Lauvås, A J, Skovmand, A, Poulsen, M S, Kyjovska, Z O, Roursgaard, M, Goericke-Pesch, S, Vogel, U & Hougaard, K S 2019, ' Airway exposure to TiO 2 nanoparticles and quartz and effects on sperm counts and testosterone levels in male mice ', Reproductive Toxicology, vol. 90, pp. 134-140 . https://doi.org/10.1016/j.reprotox.2019.07.023 |
| Popis: | Several types of engineered nanoparticles (ENP) have been shown to adversely affect male reproduction in rodent studies, but the airway route of exposure has been little investigated. This precludes adequate risk assessment of ENP exposure in occupational settings. Titanium dioxide nanoparticles (TiO2 NP) have been shown to affect total sperm count in adult male mice after intravenous and oral administration. This study aimed to investigate whether also airway exposure would affect sperm counts in male mice. Mature C57BL/6J mice were intratracheally instilled with 63 μg of rutile nanosized TiO2, once weekly for seven weeks. Respirable α-quartz (SRM1878a) was included at a similar dose level as a positive control for pulmonary inflammation. BALF cell composition showed neutrophil granulocyte influx as indication of pulmonary inflammation in animals exposed to TiO2 NP and α-quartz, but none of the particle exposures affected weight of testes or the epididymis, sperm counts or plasma testosterone when assessed at termination of the study. |
| Databáze: | OpenAIRE |
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