Discovery of α-amidosulfones as potent and selective agonists of CB2: Synthesis, SAR, and pharmacokinetic properties

Autor:	Ryan White, Erin F. DiMauro, Stephen Hitchcock, Robert T. Fremeau, Ming Y. Huang, Isaac E. Marx, Jason Brooks Human, Liyue Huang, Josie H. Lee, Alan C. Cheng, Vinod F. Patel, Xingwen Li, Matthew W. Martin, Renee Emkey
Rok vydání:	2009
Předmět:	Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Pharmacology Amides Biochemistry Rats Receptor Cannabinoid CB2 Structure-Activity Relationship Pharmacokinetics Drug Discovery Microsomes Liver Animals Humans Molecular Medicine Sulfones Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 19:31-35
ISSN:	0960-894X
Popis:	A series of α-amidosulfones were found to be potent and selective agonists of CB2. The discovery, synthesis, and structure–activity relationships of this series of agonists are reported. In addition, the pharmacokinetic properties of the most promising compounds are profiled.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e0daa5a47b3ce311b575c1293b5ea28 https://doi.org/10.1016/j.bmcl.2008.11.026 Zobrazit plný text záznamu Full Text from ScienceDirect