The effect of cartilage-derived morphogenetic protein 2 on initial healing of a rotator cuff defect in a rat model
| Autor: | Frederick J. Kummer, Douglas H. Murray, Joseph D. Zuckerman, Mark I. Loebenberg, Laith M. Jazrawi, Arash Araghi, Erik N. Kubiak |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Supraspinatus muscle Bone morphogenetic protein Rotator Cuff Injuries Rats Sprague-Dawley Rotator Cuff medicine Animals Orthopedics and Sports Medicine Rotator cuff Wound Healing business.industry Cartilage Rotator cuff injury General Medicine medicine.disease Rats Surgery Tendon Disease Models Animal medicine.anatomical_structure Bone Morphogenetic Proteins Tears Wound healing business |
| Zdroj: | Journal of Shoulder and Elbow Surgery. 16:251-254 |
| ISSN: | 1058-2746 |
| Popis: | This animal study evaluated the healing of supraspinatus tendon tears by use of a cartilage-derived morphogenetic protein 2 growth factor (CDMP-2) delivered to the repair. Forty-eight rats had bilateral, surgically created complete tears repaired by sutures with the growth factor introduced on one side. They were killed at 2, 3, 4, and 6 weeks, and the strength of the repairs was determined and histologic analysis performed. At 4 and 6 weeks, the CDMP-2-treated repairs were significantly stronger than the untreated repairs and histologic analysis showed more organized healing. The use of growth factors introduced at the time of rotator cuff repair might promote more rapid healing and subsequent, rapid patient rehabilitation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect