Do preoperative serum vascular endothelial growth factor and migration-inhibitory factor predict the nature of the adnexal masses? A prospective-controlled trial

Autor: Çağdaş Aktan, Mustafa Cosan Terek, Cumhur Gündüz, Yılmaz Dikmen, Nuri Yildirim, Osman Zekioglu, Levent Akman, Nur Selvi Günel
Rok vydání: 2016
Předmět:
Adult
medicine.medical_specialty
Pathology
Gastroenterology
Adnexal mass
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Ascites
Humans
Medicine
Prospective Studies
Stage (cooking)
Prospective cohort study
Macrophage Migration-Inhibitory Factors
Aged
Ovarian Neoplasms
030219 obstetrics & reproductive medicine
Vascular Endothelial Growth Factors
business.industry
Obstetrics and Gynecology
Middle Aged
Prognosis
medicine.disease
female genital diseases and pregnancy complications
Intramolecular Oxidoreductases
Vascular endothelial growth factor
Adnexal Diseases
chemistry
CA-125 Antigen
030220 oncology & carcinogenesis
Preoperative Period
Female
Macrophage migration inhibitory factor
medicine.symptom
business
Ovarian cancer
Zdroj: Journal of Obstetrics and Gynaecology. 36:533-537
ISSN: 1364-6893
0144-3615
DOI: 10.3109/01443615.2015.1121978
Popis: The aim of this study was to identify the role of preoperative serum vascular endothelial growth factor (VEGF) and migration inhibitor factor (MIF) in differentiation of benign and malignant adnexal masses, as well as the relationship between prognostic factors and VEGF and MIF in ovarian cancer patients. This prospective study included 41 patients who were admitted between November 2010 and March 2012. In the malignant group, there were 21 patients, and remaining 20 had benign adnexal masses. Age, CA125 levels, grade, stage, presence of ascites and the degree of cytoreduction performed were noted. There was no significant difference between two groups in preoperative serum VEGF and MIF levels (p = 0.118 and p = 0.297, respectively). CA125 levels were significantly higher in the malignant group (p
Databáze: OpenAIRE
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