Effects of the GluN2B-NMDA receptor antagonist Ro 25-6981 on two types of behavioral flexibility in rats
| Autor: | Emma Clark, Kristen Antoniak, Alyssandra Feniquito, Hans C. Dringenberg |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Spatial Behavior Reversal Learning Water maze Biology Receptors N-Methyl-D-Aspartate 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Phenols Piperidines Reaction Time Spatial strategy Animals Attention Rats Long-Evans Maze Learning Analysis of Variance Communication business.industry Cognitive flexibility Flexibility (personality) Motor strategy Rats 030104 developmental biology Escape platform Exploratory Behavior NMDA receptor business Early phase Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Behavioural Brain Research. 319:225-233 |
| ISSN: | 0166-4328 |
| Popis: | Recent evidence has implicated N- methyl- d -aspartate receptors (NMDARs) in several aspects of learning and behavioral flexibility in rodents. Here, we examined the effects of treatment with Ro 25-6981, a selective antagonist of NMDARs containing GluN2B subunits, on two types of behavioral flexibility in rats, spatial reversal learning and set-shifting (spatial vs. motor strategy). To examine spatial reversal learning, rats were trained to swim to a hidden platform in a water maze over four days. On the following day, the platform was moved to a new location in the maze. Administration of Ro 25-6981 (10 mg/kg) selectively impaired the early phase of reversal learning, but all rats learned to navigate to the new platform location over 12 trials. To examine set-shifting, independent groups of rats were trained to either swim to a fixed location (spatial strategy) or use a motor response (e.g., “turn left”; motor strategy) to find a hidden escape platform in a cross-shaped water maze apparatus; after task acquisition, rats were trained on the second, novel strategy (set-shift) following treatment with either Ro 25-6981 (10 mg/kg) or saline. Administration of Ro 25-6981 had no effect on the ability of rats to perform the set-shift and use the new strategy to locate the escape platform. These results suggest that, in rats, spatial reversal learning, but not set-shifting, is sensitive to Ro-25-6981 treatment. Thus, NMDARs-GluN2B signaling may play a selective role in some forms of behavioral plasticity, particularly for situations involving the updating of information in the spatial domain. |
| Databáze: | OpenAIRE |
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