Risk Factors for COVID-19 and Rheumatic Disease Flare in a US Cohort of Latino Patients
| Autor: | Sandra G. Williams, Alice Fike, Jun Chu, Pravitt Gourh, Michael M. Ward, James D. Katz, Sarfaraz Hasni, Yanira Ruiz-Perdomo, Julia Hartman, Christopher Redmond |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Immunology Disease Comorbidity Logistic regression Severity of Illness Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Rheumatology Risk Factors Intensive care Internal medicine Rheumatic Diseases Medicine Immunology and Allergy Humans 030212 general & internal medicine Risk factor Retrospective Studies 030203 arthritis & rheumatology business.industry Incidence Brief Report COVID-19 Retrospective cohort study Odds ratio Hispanic or Latino Middle Aged United States Cohort Female Brief Reports business Body mass index |
| Zdroj: | Arthritis & Rheumatology (Hoboken, N.j.) Arthritis & Rheumatology |
| ISSN: | 2326-5205 |
| Popis: | OBJECTIVE Latino patients are overrepresented among cases of coronavirus disease 2019 (COVID-19) and are at an increased risk of severe disease. Prevalence of COVID-19 in Latinos with rheumatic diseases is poorly reported. This study was undertaken to characterize COVID-19 clinical features and outcomes in Latino patients with rheumatic diseases. METHODS We conducted a retrospective study of Latino patients with rheumatic diseases from an existing observational cohort in the Washington, DC area. Patients seen between April 1, 2020 and October 15, 2020 were analyzed in this study. We reviewed demographic characteristics, body mass index (BMI), comorbidities, and use of immunomodulatory therapies. An exploratory classification and regression tree (CART) analysis along with logistic regression analyses were performed to identify risk factors for COVID-19 and rheumatic disease flare. RESULTS Of 178 Latino patients with rheumatic diseases, 32 (18%) were identified as having COVID-19, and the incidence rate of infection was found to be 3-fold higher than in the general Latino population. No patients required intensive care unit-level care. A CART analysis and multivariable logistic regression analysis identified a BMI of >30.35 as a risk factor for COVID-19 (odds ratio [OR] 3.37 [95% confidence interval (95% CI) 1.5-7.7]; P = 0.004). COVID-19 positivity was a risk factor for rheumatic disease flare (OR 4.57 [95% CI 1.2-17.4]; P = 0.02). CONCLUSION Our findings indicate that Latino patients with rheumatic diseases have a higher rate of COVID-19 compared with the general Latino population. Obesity is a risk factor for COVID-19, and COVID-19 is a risk factor for rheumatic disease flare. Latino patients with risk factors should be closely followed up, especially post-COVID-19 in anticipation of disease flare. |
| Databáze: | OpenAIRE |
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