Shift in prevalence of HPV types in cervical cytology specimens in the era of HPV vaccination
Autor: | Cyril Bank, Andreas Gaumann, Marcus Bettstetter, Andrea Becher, Ingrid Becker, Arndt Hartmann, Sonja Fischer, Wolfgang Jagla, Marlene Lessel, Matthias Krams |
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Rok vydání: | 2015 |
Předmět: |
Cancer Research
medicine.medical_specialty Population 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine education Cervical cancer education.field_of_study Hpv types business.industry HPV infection Cancer virus diseases Articles medicine.disease female genital diseases and pregnancy complications Vaccination Oncology Cytopathology 030220 oncology & carcinogenesis Immunology business Cohort study |
Zdroj: | Oncology letters. 12(1) |
ISSN: | 1792-1074 |
Popis: | The aim of the present population-based cohort study was to analyze the association between the prevalence of 32 types of human papilloma virus (HPV) in 615 female patients with abnormal cervical cytopathology findings. In total, 32 HPV types were screened by DNA array technology. HPV infection was detected in 470 women (76.42%), 419 of whom (89.15%) were infected with ≥1 high-risk (HR)-HPV type. HPV16, which is recognized as the main HR-HPV type responsible for the development of cervical cancer, was observed in 32.98% of HPV+ participants, followed by HPV42 (18.09%), HPV31 (17.66%), HPV51 (13.83%), HPV56 (10.00%), HPV53 (8.72%) and HPV66 (8.72%). The prevalence of HR-HPV types, which may be suppressed directly (in the case of HPV16 and 18), or possibly via cross-protection (in the case of HPV31) following vaccination, was considerably lower in participants ≤22 years of age (HPV16, 28.57%; HPV18, 2.04%; HPV31, 6.12%), compared with participants 23-29 years of age (HPV16, 45.71%; HPV18, 7.86%; HPV31, 22.86%), who were less likely to be vaccinated. Consequently, the present study hypothesizes that there may be a continuous shift in the prevalence of HPV types as a result of vaccination. Furthermore, the percentage of non-vaccine HR-HPV types was higher than expected, considering that eight HPV types formerly classified as 'low-risk' or 'probably high-risk' are in fact HR-HPV types. Therefore, it may be important to monitor non-vaccine HPV types in future studies, and an investigation concerning several HR-HPV types as risk factors for the development of cervical cancer is required. |
Databáze: | OpenAIRE |
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