Metabolic Adaptations of Skeletal Muscle to Voluntary Wheel Running Exercise in Hypertensive Heart Failure Rats
| Autor: | R. L. Schultz, H. Huang, A. M. Gerdes, Emily L. Kullman, Robert P. Waters, John G. Swallow, John P. Kirwan |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Time Factors Physiology Physical Exertion Rats Inbred WF Hindlimb Oxidative phosphorylation Running Muscle hypertrophy chemistry.chemical_compound Rats Inbred SHR Internal medicine Animals Citrate synthase Medicine Aerobic exercise RNA Messenger Muscle Skeletal Heart Failure biology Glycogen business.industry 3-Hydroxyacyl CoA Dehydrogenases Skeletal muscle General Medicine medicine.disease Adaptation Physiological Rats Disease Models Animal Endocrinology medicine.anatomical_structure chemistry Heart failure Hypertension ATP Citrate (pro-S)-Lyase biology.protein Female Energy Metabolism business Glycolysis Muscle Contraction |
| Zdroj: | Physiological Research. :361-369 |
| ISSN: | 1802-9973 0862-8408 |
| DOI: | 10.33549/physiolres.932330 |
| Popis: | The Spontaneously Hypertensive Heart Failure (SHHF) rat mimics the human progression of hypertension from hypertrophy to heart failure. However, it is unknown whether SHHF animals can exercise at sufficient levels to observe beneficial biochemical adaptations in skeletal muscle. Thirty-seven female SHHF and Wistar-Furth (WF) rats were randomized to sedentary (SHHFsed and WFsed) and exercise groups (SHHFex and WFex). The exercise groups had access to running wheels from 6-22 months of age. Hindlimb muscles were obtained for metabolic measures that included mitochondrial enzyme function and expression, and glycogen utilization. The SHHFex rats ran a greater distance and duration as compared to the WFex rats (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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