Quantitative morphology
| Autor: | J. G. Stolk, J. Oort, H. R. Franke, F. J. M. Caron, M. C. Boog, C. L. Alons |
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| Rok vydání: | 1985 |
| Předmět: |
medicine.medical_specialty
Pathology Trophoblastic Tumor Quantitative morphology Biology Malignancy Pathology and Forensic Medicine Chorioepithelioma Pregnancy Internal medicine medicine Humans Choriocarcinoma Molecular Biology reproductive and urinary physiology Significant difference Placental tissue Trophoblast Hydatidiform Mole Cell Biology General Medicine Prognosis medicine.disease female genital diseases and pregnancy complications Trophoblasts medicine.anatomical_structure Endocrinology Uterine Neoplasms embryonic structures Female Chorionic Villi |
| Zdroj: | Virchows Archiv A Pathological Anatomy and Histopathology. 406:323-331 |
| ISSN: | 1432-2307 0174-7398 |
| DOI: | 10.1007/bf00704301 |
| Popis: | It is difficult to predict the possible development of a malignant trophoblastic tumor after the evacuation of a hydatidiform mole. In order to help resolve this difficulty, a morphometric study has been carried out. The mean nuclear area of the trophoblast in a group of hydatidiform moles, followed by a trophoblastic malignancy, was found to be statistically significantly larger than that of the trophoblast in a group of hydatidiform moles which were not followed by malignant trophoblastic disease. However, the mean trophoblast/nontrophoblast ratio in villi demonstrated no statistically significant difference between those 2 groups of hydatidiform moles. Therefore it is not advisable to grade hydatidiform moles on the basis of trophoblastic proliferation alone. It is suggested that the trophoblastic lining of hydropic villi in the placental tissue of hydatidiform moles has malignant features already, but these are more pronounced in those hydatidiform moles which are subsequently followed by a choriocarcinoma. |
| Databáze: | OpenAIRE |
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