Associations between circulating resistin concentrations and left ventricular mass are not accounted for by effects on aortic stiffness or renal dysfunction

Autor: Carlos D. Libhaber, Pinhas Sareli, Vernice R. Peterson, Glenda Norman, Angela J. Woodiwiss, Gavin R. Norton, Monica Gomes
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
endocrine system diseases
030204 cardiovascular system & hematology
Kidney
Ventricular Function
Left
0302 clinical medicine
Risk Factors
Resistin
Pulse wave velocity
0303 health sciences
Ventricular Remodeling
Confounding
Aortic stiffness
Middle Aged
Inappropriate left ventricular mass
Echocardiography
Cardiology
cardiovascular system
Female
Hypertrophy
Left Ventricular
Kidney Diseases
Cardiology and Cardiovascular Medicine
hormones
hormone substitutes
and hormone antagonists
Glomerular Filtration Rate
Research Article
Adult
medicine.medical_specialty
Adipokine
Renal function
Pulse Wave Analysis
Risk Assessment
03 medical and health sciences
Vascular Stiffness
Internal medicine
medicine
Humans
cardiovascular diseases
Obesity
030304 developmental biology
Angiology
business.industry
nutritional and metabolic diseases
medicine.disease
Cross-Sectional Studies
lcsh:RC666-701
Heart failure
business
Biomarkers
Zdroj: BMC Cardiovascular Disorders, Vol 20, Iss 1, Pp 1-9 (2020)
BMC Cardiovascular Disorders
ISSN: 1471-2261
Popis: Background Although, in-part through an impact on left ventricular mass (LVM), resistin (an adipokine) may contribute to heart failure, whether this is explained by the adverse effects of resistin on aortic stiffness and renal function is unknown. Methods Relationships between circulating resistin concentrations and LVM index (LVMI), and LVM beyond that predicted by stroke work (inappropriate LVM [LVMinappr]) (echocardiography) were determined in 647 randomly selected community participants, and in regression analysis, the extent to which these relations could be explained by aortic pulse wave velocity (PWV) or estimated glomerular filtration rate (eGFR) was evaluated. Results Independent of confounders, resistin concentrations were independently associated with LVMI, LVMinappr, LV hypertrophy (LVH), PWV and eGFR. Furthermore, independent of confounders, LVMI, LVMinappr and LVH were independently associated with PWV and eGFR. However, adjustments for either PWV or eGFR failed to modify the relationships between resistin concentrations and LVMI, LVMinappr or LVH. Moreover, in multivariate regression analysis neither PWV nor eGFR significantly modified the contribution of resistin to LVMinappr or LVMI. Conclusions Independent relationships between circulating concentrations of the adipocytokine resistin and LVM are not explained by the impact of resistin on ventricular-vascular coupling or renal dysfunction. Resistin’s effects on LVM are therefore likely to be through direct actions on the myocardium.
Databáze: OpenAIRE
Externí odkaz: