Cytoprotective effect of trimetazidine on 60 minutes of intestinal ischemia-reperfusion injury in rats

Autor: Özgür Yis, Birol Bostanci, Ayse Bilgihan, Nese Calli, Cihat Tetik, Hatice Bayramoglu, Akın Özden
Rok vydání: 1999
Předmět:
Male
antioxidant
Time Factors
Antioxidant
medicine.medical_treatment
Trimetazidine
Pharmacology
Antioxidants
Rats
Sprague-Dawley
Lipid peroxidation
chemistry.chemical_compound
Malondialdehyde
Medicine
rat
Intestinal Mucosa
Myeloperoxidase
biology
malonaldehyde
article
neutrophil
lipid peroxidation
Free Radical Scavengers
reperfusion injury
Free radical scavenger
intravenous drug administration
priority journal
Biochemistry
Reperfusion Injury
histopathology
intestine mucosa
medicine.drug
kidney
cell protection
trimetazidine
animal experiment
Ischemia
liver
intestine ischemia
animal tissue
Mesenteric Veins
male
Ileum
Mesenteric Artery
Superior
Animals
controlled study
scavenger
Peroxidase
Intestinal ischemia
Transplantation
nonhuman
business.industry
animal model
heart muscle
Antioxidants/pharmacology
Free Radical Scavengers/pharmacology
Intestinal Mucosa/*blood supply/drug effects/pathology
Malondialdehyde/metabolism
Mesenteric Artery
Superior/physiology
Mesenteric Veins/physiology
Peroxidase/metabolism
Rats
Reperfusion Injury/*prevention & control
Trimetazidine/*pharmacology
medicine.disease
chemistry
biology.protein
intestinal ischemia
malondialdehyde
business
Reperfusion injury
Zdroj: Transplant International. 12:108-112
ISSN: 1432-2277
0934-0874
DOI: 10.1007/s001470050194
Popis: Trimetazidine (TMZ), a potent antioxidant agent, has been used to protect the myocardium, liver and kidney from ischemia reperfusion (IR) injury. We investigated the effect of TMZ, a cellular anti-ischemic agent and a free radical scavenger, on 60 min of warm intestinal IR injury in rats. Sprague-Dawley rats were divided into three groups: a sham-operated group (no IR injury, n = 8), an ischemic control group (control, n = 8), and a TMZ- treated group (3 mg/kg, n = 8). Malondialdehyde (MDA) levels, myeloperoxidase (MPO) activity, and mucosal damage were investigated after 120 min of reperfusion. MDA levels and MPO activity were more elevated and histopathological damage more severe in the control group than in the sham group (P < 0.05). MDA levels and MPO activity were lower and there was less histopathological damage in the TMZ group than in the control group (P < 0.05). Accumulation of lipid peroxidation products and neutrophils in mucosal tissues were significantly inhibited by TMZ treatment. We conclude that pretreatment of rats with TMZ before intestinal ischemia attenuates but does not prevent, histological damage.
Databáze: OpenAIRE
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