A transcriptomics approach to expand therapeutic options and optimize clinical trials in oncology
| Autor: | Vladimir Lazar, Baolin Zhang, Shai Magidi, Christophe Le Tourneau, Eric Raymond, Michel Ducreux, Catherine Bresson, Jacques Raynaud, Fanny Wunder, Amir Onn, Enriqueta Felip, Josep Tabernero, Gerald Batist, Razelle Kurzrock, Eitan Rubin, Richard L. Schilsky |
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| Přispěvatelé: | Institut Català de la Salut, [Lazar V] Worldwide Innovative Network (WIN) Association–WIN Consortium, Villejuif, France. [Zhang B] Office of Biotechnology Products (OBP), Center for Drug Evaluation and Research (CDER), Food and Drug Administration (FDA), Silver Spring, MA, USA. [Magidi S] Worldwide Innovative Network (WIN) Association–WIN Consortium, Villejuif, France. [Le Tourneau C] Department of Drug Development and Innovation (D3i), Inserm, Research Unit, Paris-Saclay University, Institut Curie, Paris, France. [Raymond E] Oncology Department, Groupe Hospitalier Paris Saint Joseph, Paris, France. [Ducreux M] Department of Medical Oncology, Gustave Roussy, Université Paris-Saclay, Inserm, Villejuif, France. [Felip E, Tabernero J] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. UVic-UCC, Barcelona, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Medicaments - Desenvolupament
técnicas de investigación::técnicas genéticas::perfiles de expresión génica [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] profesiones sanitarias::medicina::medicina interna::oncología médica [DISCIPLINAS Y OCUPACIONES] Oncology Oncologia Investigative Techniques::Genetic Techniques::Gene Expression Profiling [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] técnicas de investigación::desarrollo de medicamentos [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Expressió gènica Health Occupations::Medicine::Internal Medicine::Medical Oncology [DISCIPLINES AND OCCUPATIONS] Investigative Techniques::Drug Development [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] |
| Zdroj: | Scientia |
| Popis: | Oncology; Transcriptomics; Tumor biopsies Oncologia; Transcriptòmica; Biòpsies tumorals Oncología; Transcriptómica; Biopsias tumorales Background: The current model of clinical drug development in oncology displays major limitations due to a high attrition rate in patient enrollment in early phase trials and a high failure rate of drugs in phase III studies. Objective: Integrating transcriptomics for selection of patients has the potential to achieve enhanced speed and efficacy of precision oncology trials for any targeted therapies or immunotherapies. Methods: Relative gene expression level in the metastasis and normal organ-matched tissues from the WINTHER database was used to estimate in silico the potential clinical benefit of specific treatments in a variety of metastatic solid tumors. Results: As example, high mRNA expression in tumor tissue compared to analogous normal tissue of c-MET and its ligand HGF correlated in silico with shorter overall survival (OS; p |
| Databáze: | OpenAIRE |
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