Understanding the effect of alkyl chains of gemini cations on the physicochemical and cellular properties of polyurethane micelles
Autor: | Jianshu Li, Hong Tan, Zhicheng Pan, Feng Luo, Nijia Song, Jiehua Li, Mingming Ding, Qiang Fu, Danxuan Fang, Yuanqing Song |
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Rok vydání: | 2018 |
Předmět: |
Cell Survival
Polyurethanes Static Electricity Biomedical Engineering 02 engineering and technology 010402 general chemistry 01 natural sciences Micelle Mice Structure-Activity Relationship Cations Static electricity Animals Humans General Materials Science Alkyl Micelles chemistry.chemical_classification Drug Carriers Chemistry Cationic polymerization Rational design Biological Transport Fibroblasts 021001 nanoscience & nanotechnology 0104 chemical sciences Quaternary Ammonium Compounds RAW 264.7 Cells Drug delivery Biophysics Nanoparticles lipids (amino acids peptides and proteins) Nanocarriers 0210 nano-technology Drug carrier HeLa Cells |
Zdroj: | Biomaterials science. 6(7) |
ISSN: | 2047-4849 |
Popis: | Cationic gemini quaternary ammonium (GQA) has been used as a cell internalization promoter to improve the permeability of the cell membrane and enhance the cellular uptake. However, the effect of the alkyl chain length on the cellular properties of nanocarriers has not been elucidated yet. In this study, we developed a series of polyurethane micelles containing GQAs with various alkyl chain lengths. The alteration of the gemini alkyl chain length was found to change the distribution of GQA surfactants in the micellar structure and affect the surface charge exposure, stability, and the protein absorption properties of nanocarriers. Moreover, we also clarified the role of the alkyl chain length in tumor cell internalization and macrophage uptake of polyurethane micelles. This work provides a new understanding on the effect of the GQA alkyl chain length on the physicochemical and biological properties of nanomedicines, and offers guidance on the rational design of effective drug delivery systems where the issue of functional group exposure at the micellar surface should be considered. |
Databáze: | OpenAIRE |
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