LINC complex regulation of genome organization and function
| Autor: | Xianrong Wong, Colin L. Stewart, Tsui-Han Loo |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cytoplasm
Nuclear Envelope LINC complex Computational biology Biology Genome Mechanotransduction Cellular 03 medical and health sciences 0302 clinical medicine Protein structure Genetics medicine Humans Mechanotransduction Cytoskeleton 030304 developmental biology Genomic organization Cell Nucleus 0303 health sciences Nuclear Proteins medicine.anatomical_structure RNA Long Noncoding Nucleus 030217 neurology & neurosurgery Function (biology) Developmental Biology |
| Zdroj: | Current opinion in geneticsdevelopment. 67 |
| ISSN: | 1879-0380 |
| Popis: | The regulation of genomic function is in part mediated through the physical organization and architecture of the nucleus. Disruption to nuclear organization and architecture is increasingly being recognized by its contribution to many diseases. The LINC complexes - protein structures traversing the nuclear envelope, that physically connect the nuclear interior, and hence the genome, to cytoplasmic cytoskeletal networks are an important component in the physical organization of the genome and its function. This connection, potentially allows for the constant detection of environmental mechanical stimuli, resulting in altered regulation of nuclear architecture and genome function, either directly or via the process of mechanotransduction. Here, we review the influences LINC complexes exert on genome functions and their impact on cellular/organismal health. |
| Databáze: | OpenAIRE |
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