Expression of KIR2DL3 and KIR2DS2 Natural Killer Receptors in Exercise
| Autor: | S. A. Khaustova, E. A. Tonevitsky, D. A. Sakharov, E. S. Grebenyuk, N. P. Obraztsova, M. Yu. Shkurnikov, V. A. Shleptsova |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Stimulation General Medicine Biology General Biochemistry Genetics and Molecular Biology GZMB Endocrinology Immune system Receptors KIR Receptors KIR2DL3 Transcription (biology) Heat shock protein Internal medicine Gene expression medicine Humans Receptors Natural Killer Cell Receptor Exercise Gene |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 149:755-758 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The mechanisms of early activation of natural killers were studied in volunteers of different athletic qualification. The initial levels of expression of KIR2DL2, PRF1, and GZMB genes regulating the functions of natural killer differ in athletes and untrained subjects. Moderate exercise stimulates transcription activities of these genes. In athletes, the expression increases more intensely than in controls. Stimulation of inhibitory (KIR2DL3) and activation (KIR2DS2) receptors was revealed. This indicated nonspecific stimulation of natural killers, probably mediated by an increase in serum concentration of heat shock protein with a molecular weight of 70 kDa. |
| Databáze: | OpenAIRE |
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