| Autor: |
Qi-jian Su, Hui Jiang, Yu Zhang, Li-jing Huang |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
AIDS research and human retroviruses. |
| ISSN: |
1931-8405 |
| Popis: |
Persistent inflammation contributes to the exhaustion of immune system and non-AIDS-defining events in HIV-infected patients. Transforming growth factor β (TGF-β) is generally considered an anti-inflammatory cytokine. It is unclear that why high-level TGF-β coexists with chronic inflammation during HIV infection. In the present study, it was found that HIV-infected patients had lower proportion of phosphorylated Smad2/3-posive cells among total CD3+ T cells and subsets of CD3+CD8+ and CD3+CD8- T cells when compared with health subjects. The findings implied that phosphorylation of Smad2/3 is inhibited in HIV-infected patients, and that disturbance of TGF-β/Smad signaling pathway may be involved in HIV-related chronic inflammation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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