N-Alkylation of phenethylamine and tryptamine
| Autor: | Michael K. Whittlesey, Gerta Cami-Kobeci, Paul A. Slatford, Jonathan M. J. Williams |
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| Rok vydání: | 2005 |
| Předmět: |
Tryptamine
Phenethylamine Alkylation Chemistry Organic Chemistry Clinical Biochemistry Diol Borrowing hydrogen Pharmaceutical Science Substrate (chemistry) General Medicine Combinatorial chemistry Biochemistry Tryptamines Catalysis chemistry.chemical_compound Catalytic cycle Cyclization Alcohols Phenethylamines Drug Discovery Molecular Medicine Organic chemistry Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 15:535-537 |
| ISSN: | 0960-894X |
| Popis: | A clean and efficient method for the N-alkylation of tryptamine and phenethylamine, employing alcohols as the alkylating agents, has been developed. The reaction proceeds via catalytic electronic activation, involving an iridium catalyst which activates the alcohol by borrowing hydrogen from the substrate, returning it later in the catalytic cycle. Some examples of N-heterocyclisation have been performed employing a diol as the substrate. |
| Databáze: | OpenAIRE |
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