Dendritic Integration in Hippocampal Dentate Granule Cells
| Autor: | Stefan Remy, Heinz Beck, Roland Krueppel |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
methods [Microscopy]
Patch-Clamp Techniques Small diameter physiology [Excitatory Postsynaptic Potentials] Neuroscience(all) Action Potentials Hippocampal formation Biology Synaptic Transmission statistics & numerical data [Computer Simulation] methods [Patch-Clamp Techniques] physiology [Dentate Gyrus] physiology [Action Potentials] medicine Animals Computer Simulation ddc:610 cytology [Dentate Gyrus] Rats Wistar Microscopy methods [Electrophysiology] physiology [Pyramidal Cells] Pyramidal Cells General Neuroscience Hippocampus proper Granule (cell biology) Glutamate receptor Excitatory Postsynaptic Potentials Dendrites physiology [Dendrites] Entorhinal cortex Granule cell Rats Electrophysiology medicine.anatomical_structure physiology [Synaptic Transmission] Dentate Gyrus Neuroscience |
| Zdroj: | Neuron 71(3), 512-528 (2011). doi:10.1016/j.neuron.2011.05.043 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/j.neuron.2011.05.043 |
| Popis: | SummaryHippocampal granule cells are important relay stations that transfer information from the entorhinal cortex into the hippocampus proper. This process is critically determined by the integrative properties of granule cell dendrites. However, their small diameter has so far hampered efforts to examine their properties directly. Using a combination of dual somatodendritic patch-clamp recordings and multiphoton glutamate uncaging, we now show that the integrative properties of granule cell dendrites differ substantially from other principal neurons. Due to a very strong dendritic voltage attenuation, the impact of individual synapses on granule cell output is low. At the same time, integration is linearized by voltage-dependent boosting mechanisms, only weakly affected by input synchrony, and independent of input location. These experiments establish that dentate granule cell dendritic properties are optimized for linear integration and strong attenuation of synaptic input from the entorhinal cortex, which may contribute to the sparse activity of granule cells in vivo. |
| Databáze: | OpenAIRE |
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