Melatonin treatment of pigs with acute pancreatitis reduces inflammatory reaction of pancreatic tissue and enhances fitness score of pigs: experimental research
| Autor: | Jakob R. Izbicki, Annika Poppe, Oliver Mann, Katharina Grupp, Karin H. Wodack, Johannes Erbes, Andreas Gocht, Kai Bachmann, Constantin Trepte, Jan Havel |
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| Rok vydání: | 2019 |
| Předmět: |
Fitness score
medicine.medical_specialty Antioxidant Necrosis Swine medicine.medical_treatment lcsh:Surgery Adipose tissue Inflammation Gastroenterology Melatonin Germany Internal medicine Edema medicine Animals Experimental model Pancreas business.industry Pancreatic tissue lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RD1-811 lcsh:RC86-88.9 medicine.disease Survival Analysis Acute pancreatitis Disease Models Animal Treatment Outcome Pancreatitis Physical Fitness Emergency Medicine Surgery medicine.symptom business hormones hormone substitutes and hormone antagonists Research Article medicine.drug |
| Zdroj: | World Journal of Emergency Surgery, Vol 14, Iss 1, Pp 1-8 (2019) World Journal of Emergency Surgery : WJES |
| ISSN: | 1749-7922 |
| Popis: | Background Severe acute pancreatitis is associated with high morbidity and mortality. Melatonin is known as the activator of antioxidant enzymes. The main purpose of this study was to evaluate the clinical effect of melatonin treatment in a pig model with induced acute pancreatitis. Methods In this study, acute pancreatitis was induced in 38 German domestic pigs (German Hybrid). After induction of acute pancreatitis, 18 animals were treated with melatonin. Intraoperative clinical data, postoperative blood parameters, fitness, and Porcine Well-being (PWB) score, and post-mortal histopathological data were analyzed in both study groups. Results The matching procedure created two groups (melatonin group and control group) which were very similar. The fitness and PWB score were postoperative significantly enhanced in the melatonin group as compared to the control group (p = 0.005 and p = 0.003). Additionally, histological analysis revealed that acinar necrosis, fat tissue necrosis, and edema were significantly reduced in the melatonin group as compared to the non-melatonin group (p = 0.025, p = 0.003, and p = 0.028). Conclusions Pigs, which were treated with melatonin, were characterized by higher fitness and PWB scores than those of the control group. Moreover, melatonin treatment reduces the acinar necrosis, fat tissue necrosis, and edema of pancreatic tissue. Thus, melatonin might be a useful therapeutic option in severe acute pancreatitis. Electronic supplementary material The online version of this article (10.1186/s13017-019-0237-2) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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