Review: A review of the use of zonisamide in Parkinson’s disease
| Autor: | Buenaventura Anciones, Pedro Emilio Bermejo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
medicine.medical_specialty Parkinson's disease Essential tremor Side effect business.industry Zonisamide Disease medicine.disease lcsh:RC346-429 Epilepsy Neurology Migraine Neuropathic pain Medicine Neurology (clinical) business Psychiatry Intensive care medicine lcsh:Neurology. Diseases of the nervous system medicine.drug |
| Zdroj: | Therapeutic Advances in Neurological Disorders, Vol 2 (2009) |
| ISSN: | 1756-2856 |
| Popis: | Although zonisamide was previously only used to treat epilepsy, recently more applications have been forthcoming. Due to a good side effect profile, a lower frequency of interactions and a more comfortable posology, there are several studies regarding its uses in other pathologies such as migraine, neuropathic pain, essential tremor and various psychiatric diseases. A multicentered, randomized, double-blind, placebo-controlled study conducted in Japan suggested that zonisamide, as an add-on treatment, has efficacy in treating motor symptoms in patients with Parkinson’s disease. In addition, other studies support the utility of zonisamide in other symptoms of this disease. The therapeutic doses of zonisamide for the treatment of Parkinson’s disease are considerably lower than those for the treatment of epilepsy. This antiepileptic drug has been used in Japan for more than 15 years and so it is expected that it will be safe and well tolerated in patients with Parkinson’s disease. However, the pharmacological mechanisms of the antiparkinsonian actions of zonisamide remain unclear and more basic investigation is warranted. The aim of this paper is to review the structure, mechanisms of action, pharmacokinetics and antiparkinsonian action of zonisamide. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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