Selective intracellular delivery of thiolated cargo to tumor and neovasculature cells using histidine-rich peptides as vectors
| Autor: | Terje Vasskog, John S. Svendsen, J. Johannes Eksteen, Øystein Rekdal, Dominik Ausbacher |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Chemistry
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 General Chemical Engineering Zinc ion technology industry and agriculture Disulfide bond General Chemistry Article VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 Biochemistry Cytotoxic T cell QD1-999 Intracellular Histidine |
| Zdroj: | ACS Omega ACS Omega, Vol 5, Iss 10, Pp 4937-4942 (2020) |
| Popis: | Short histidine-rich peptides could serve as novel activatable vectors for delivering cytotoxic payloads to tumor and neovasculature cells. This explorative study reports preliminary results showing that zinc ions, which are found in elevated levels at neovasculature sites, can trigger the intracellular delivery of a short antimicrobial peptide when conjugated to a histidine-rich peptide through a disulfide bond. The importance of exofacial thiols in the mode of action of these disulfide-linked conjugates is also shown. publishedVersion |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|