Oral contraception can decrease the pituitary capacity to release gonadotrophins in response to synthetic LH-releasing-hormone

Autor: Taubert Hd, Jürgensen O, C. Robyn, J. S. E. Dericks-Tan, H. Schöndorf
Rok vydání: 1973
Předmět:
Zdroj: Archiv f�r Gyn�kologie. 216:73-80
ISSN: 1432-0711
0003-9128
DOI: 10.1007/bf00672676
Popis: Measurements of plasma levels of LH and FSH before and after injection of LH-releasing hormone (LH-RH) in women who have been on oral contraceptives, to determine whether the release of FSH and LH is affected by the chronic administration of oral contraceptives were donducted. 5 women, ages 24-34 years, who were taking oral contraceptives for 12-36 months, were studied, between Days 22 and 24 of the cycle. They received 12.5 mcg LH-RH on Day 1 and 25 mcg on Day 2 of the study. LH and FSH were measured by radioimmunoassay using the double-antibody method. 5 control women were also used. In all 5 control volunteers, serum LH rose rapidly within 5 minutes after the injection of 12.5 mcg LH-RH. In 4 out of 5 cases, an increase of plasma FSH was demonstrable after application of LH-RH. The increments were smaller than for LH. With the 5 women on oral contraceptives, much lower basal values of LH and diminished FSH levels were found. When the 5 test women were injected on Day 2 with 25 mcg LH-RH, the amounts of LH and FSH released were not significantly different from those of Day 1. The amounts of LH and FSH released in response to the intravenous administration of LH-RH were found to be severely impeded in 4 out of 5 women taking oral contraceptives for long periods of time. Long-term administration of oral contraceptives seems to limit the reserve capacity of the pituitary to release gonadotropins.
Databáze: OpenAIRE
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