The Metabolism and Distribution of Docosapentaenoic Acid (n-6) in the Liver and Testis of Growing Rats
| Autor: | Yoko Fujiwara, Phyllis S. Y. Tam, Yan Cui, Akiyo Matsumoto, Rumi Sawada |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Linoleic acid delta-6 desaturase Biology Applied Microbiology and Biotechnology Biochemistry Linoleoyl-CoA Desaturase Gene Expression Regulation Enzymologic Analytical Chemistry chemistry.chemical_compound Internal medicine Testis medicine arachidonic acid Weaning Animals retroconversion RNA Messenger docosapentaenoic acid Molecular Biology chemistry.chemical_classification Organic Chemistry Fatty acid Docosapentaenoic Acid n-6 General Medicine Metabolism Organ Size docosahexaenoic acid Animal Feed Rats Endocrinology Milk chemistry Liver Docosahexaenoic acid Fatty Acids Unsaturated Arachidonic acid Female Docosapentaenoic acid Biotechnology |
| Zdroj: | Bioscience, Biotechnology, and Biochemistry. 72(10):2548-2554 |
| ISSN: | 0916-8451 |
| Popis: | To investigate the metabolism and distribution of docosapentaenoic acid (22:5n-6, DPA) in the liver and testis of growing rats, 22:5n-6 was administered to their dams. Newborn rats with a low hepatic arachidonic acid (20:4n-6, AA) level were generated by administrating a diet rich in docosahexaenoic acid (22:6n-3, DHA) but n-6 fatty acid (FA) free to pregnant dams. After parturition, 22:5n-6 or linoleic acid (18:2n-6, LA) was administered with a high level of 22:6n-3 to the dams until weaning. At weaning, the hepatic 20:4n-6 level was significantly highest in the DPA-DHA but not LA-DHA diet-fed animals. The hepatic delta-6 desaturase (D6D) mRNA abundance was significantly lower in both the LA-DHA and DPA-DHA diet-fed animals, connoted with the 20:4n-6 content recovered by 22:5n-6 that did not involve D6D and supporting the occurrence of retroconversion in the liver of the growing rats. The low D6D level in the 3-week-old testis was not in proportion to the elevated 22:5n-6 level, implying that early testicular 22:5n-6 accumulation might require supply from the circulation system. |
| Databáze: | OpenAIRE |
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