Prognosis Impact of Diabetes in Elderly Women and Men with Non-ST Elevation Acute Coronary Syndrome
| Autor: | Gonzalo Luis Alonso Salinas, Sergio Raposeiras-Roubín, Alberto Cordero, Francisco Marcos Marín, Pablo Díez-Villanueva, Manuel Martínez-Sellés, Eduardo Núñez, Alfredo Bardají, Albert Ariza-Solé, Nuria Vicente-Ibarra, Juan M. Ruiz-Nodar, Juan Sanchis, Belén Cid-Álvarez, José María García-Acuña, Julio Núñez, Emad Abu Assi, F Formiga, José A. Barrabés |
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| Přispěvatelé: | Institut Català de la Salut, [Díez-Villanueva P] Servicio de Cardiología, Hospital Universitario La Princesa, Madrid, Spain. [García-Acuña JM] Servicio de Cardiología, Hospital Clínico Universitario de Santiago, CIBERCV, Santiago de Compostela, A Coruña, Spain. [Raposeiras-Roubin S] Servicio de Cardiología, Hospital Álvaro Cunqueiro de Vigo, Vigo, Pontevedra, Spain. [Barrabés JA] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. CIBERCV, Barcelona, Spain. [Cordero A] Servicio de Cardiología, Hospital Clínico Universitario de San Juan, Alicante, Spain. [Martínez-Sellés M] Servicio de Cardiología, Hospital Universitario Gregorio Marañón, CIBERCV, Universidad Europea, Universidad Complutense, Madrid, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Acute coronary syndrome
medicine.medical_specialty Anemia Mujer medicine.medical_treatment enfermedades nutricionales y metabólicas::enfermedades metabólicas::trastornos del metabolismo de la glucosa::diabetes mellitus [ENFERMEDADES] Enfermedad cardiovascular Anciano Otros calificadores::/diagnóstico [Otros calificadores] Dones Dietética y nutrición Disease Malalties coronàries Revascularization elderly Article Coronary diseases Infarto del miocardio sin elevación del ST non-ST-segment elevation acute coronary syndromes Diabetes mellitus Internal medicine Other subheadings::/diagnosis [Other subheadings] medicine Clinical endpoint Endocrinología Women Diagnosis::Prognosis [ANALYTICAL DIAGNOSTIC AND THERAPEUTIC TECHNIQUES AND EQUIPMENT] Diabetis - Prognosi diagnóstico::pronóstico [TÉCNICAS Y EQUIPOS ANALÍTICOS DIAGNÓSTICOS Y TERAPÉUTICOS] Diabetis business.industry ST elevation Diabetes General Medicine medicine.disease Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus [DISEASES] Diabetes mellitus tipo 2 diabetes mellitus Diferències entre sexes enfermedades cardiovasculares::enfermedades cardíacas::isquemia miocárdica::síndrome coronario agudo [ENFERMEDADES] Medicine women business Cardiovascular Diseases::Heart Diseases::Myocardial Ischemia::Acute Coronary Syndrome [DISEASES] Kidney disease |
| Zdroj: | ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) Dipòsit Digital de la UB Universidad de Barcelona Scientia Journal of Clinical Medicine, Vol 10, Iss 4403, p 4403 (2021) Journal of Clinical Medicine Volume 10 Issue 19 E-Prints Complutense. Archivo Institucional de la UCM instname |
| Popis: | Few studies have addressed to date the interaction between sex and diabetes mellitus (DM) in the prognosis of elderly patients with non-ST-segment elevation acute coronary syndrome (NSTEACS). Our aim was to address the role of DM in the prognosis of non-selected elderly patients with NSTEACS according to sex. A retrospective analysis from 11 Spanish NSTEACS registries was conducted, including patients aged ≥70 years. The primary end point was one-year all-cause mortality. A total of 7211 patients were included, 2,770 (38.4%) were women, and 39.9% had DM. Compared with the men, the women were older (79.95 ± 5.75 vs. 78.45 ± 5.43 years, p < 0.001) and more often had a history of hypertension (77% vs. 83.1%, p < 0.01). Anemia and chronic kidney disease were both more common in women. On the other hand, they less frequently had a prior history of arteriosclerotic cardiovascular disease or comorbidities such as peripheral artery disease and chronic pulmonary disease. Women showed a worse clinical profile on admission, though an invasive approach and in-hospital revascularization were both more often performed in men (p < 0.001). At a one-year follow-up, 1090 patients (15%) had died, without a difference between sexes. Male sex was an independent predictor of mortality (HR = 1.15, 95% CI 1.01 to 1.32, p = 0.035), and there was a significant interaction between sex and DM (p = 0.002). DM was strongly associated with mortality in women (HR: 1.45, 95% CI = 1.18–1.78 p < 0.001), but not in men (HR: 0.98, 95% CI = 0.84–1.14 p = 0.787). In conclusion, DM is associated with mortality in older women with NSTEACS, but not in men. |
| Databáze: | OpenAIRE |
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