HYPERPLASIA AND I131UPTAKE OF THE GUINEA PIG THYROID DURING AND AFTER CHRONIC PROPYLTHIOURACIL TREATMENT*
| Autor: | Karl E. Paschkis, Albert N. Siegel, J. L. Rivero Fontan, A. Cantarow, Savino A. D'Angelo |
|---|---|
| Rok vydání: | 1951 |
| Předmět: |
endocrine system
medicine.medical_specialty Wolff–Chaikoff effect endocrine system diseases medicine.medical_treatment Guinea Pigs Iodide Thyroid Gland Thiouracil Iodine Radioisotopes Guinea pig Endocrinology Internal medicine medicine chemistry.chemical_classification Hyperplasia business.industry Antithyroid agent Thyroid Iodides medicine.disease medicine.anatomical_structure chemistry Propylthiouracil Radioactive iodine business Iodine medicine.drug |
| Zdroj: | Endocrinology. 49:624-634 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-49-5-624 |
| Popis: | THE use of radioactive iodine and of chemical antithyroid agents in experimental studies on the thyroid gland has added considerably to present day understanding of the histophysiology of this organ. The early studies of Hertz and his colleagues (1939, 1941) and of Hamilton and Soley (1940), in which radioiodine was employed for the first time in thyroid investigation, ushered in a technic which enabled more precise interpretation of the relationship between iodine metabolism, the thyroid and the hypophysis. The observation by these investigators that hyper-plastic thyroids collected more radioiodine than normal was followed by the converse demonstration of LeBlond and collaborators (1940, 1941); namely, that the radioiodine uptake of the thyroid gland in the hypophy-sectomized animal is considerably reduced. Using tracer doses of radioactive iodine, Morton, Perlman and Chaikoff (1941) found that thyroids activated with thyrotophin rapidly converted iodide to organically-bound iodine compounds in the glan... |
| Databáze: | OpenAIRE |
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