Treatment precision of image-guided liver SBRT using implanted fiducial markers depends on marker-tumour distance
| Autor: | Wouter Wunderink, S R Wunderink-van Veen, Pascal R.M. Storchi, Ben J.M. Heijmen, Y. Seppenwoolde, A. Mendez Romero |
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| Přispěvatelé: | Radiotherapy, Clinical Genetics |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Carcinoma Hepatocellular Stereotactic body radiation therapy medicine.medical_treatment Diaphragm Metastatic liver cancer Imaging Three-Dimensional SDG 3 - Good Health and Well-being Fiducial Markers medicine Humans Radiology Nuclear Medicine and imaging Diaphragm dome Aged Radiological and Ultrasound Technology business.industry Radiotherapy Planning Computer-Assisted Liver Neoplasms Implanted Fiducial Middle Aged Image Enhancement Spine Diaphragm (structural system) Radiation therapy Female Gold Tomography Tomography X-Ray Computed Nuclear medicine business Fiducial marker Radiotherapy Image-Guided |
| Zdroj: | Physics in Medicine and Biology, 56(17), 5445-5468. IOP Publishing Ltd. |
| ISSN: | 0031-9155 |
| Popis: | The purpose of this study is to assess the accuracy of day-to-day predictions of liver tumour position using implanted gold markers as surrogates and to compare the method with alternative set-up strategies, i.e. no correction, vertebrae and 3D diaphragm-based set-up. Twenty patients undergoing stereotactic body radiation therapy (SBRT) with abdominal compression for primary or metastatic liver cancer were analysed. We determined the day-today correlation between gold marker and tumour positions in contrast-enhanced CT scans acquired at treatment preparation and before each treatment session. The influence of marker-tumour distance on the accuracy of prediction was estimated by introducing a method extension of the set-up error paradigm. The distance between gold markers and the centre of the tumour varied between 5 and 96 mm. Marker-guidance was superior to guiding treatment using other surrogates, although both the random and systematic components of the prediction error SD depended on the tumour-marker distance. For a marker-tumour distance of 4 cm, we observed sigma = 1.3 mm and Sigma = 1.6 mm. The 3D position of the diaphragm dome was the second best predictor. In conclusion, the tumour position can be predicted accurately using implanted markers, but marker-guided set-up accuracy decreases with increasing distance between implanted markers and the tumour. |
| Databáze: | OpenAIRE |
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