Impact of long‐lasting spontaneous physical activity on bone morphogenetic protein 4 in the heart and tibia in murine model of heart failure
| Autor: | Stefan Chlopicki, J Karasinski, Elżbieta Pyza, Magdalena Guzik, Joanna Majerczak, Ewa Piechowicz, Joanna Filipowska, Grzegorz Tylko, Jerzy A. Zoladz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Cardiovascular Conditions
Disorders and Treatments medicine.medical_specialty Muscle Physiology Physiology chemistry.chemical_element heart failure physical activity Physical exercise Cardiomegaly Mice Transgenic BMP4 Bone Morphogenetic Protein 4 030204 cardiovascular system & hematology Calcium Motor Activity lcsh:Physiology Bone remodeling Signalling Pathways Pathogenesis 03 medical and health sciences Mice 0302 clinical medicine Calcification Physiologic Physiology (medical) Internal medicine Physical Conditioning Animal Medicine Animals Tibia Bone mineral lcsh:QP1-981 business.industry Myocardium Endurance and Performance Heart Original Articles medicine.disease Disease Models Animal Endocrinology Bone morphogenetic protein 4 chemistry Heart failure Disease Progression Female Original Article business 030217 neurology & neurosurgery |
| Zdroj: | Physiological Reports, Vol 8, Iss 8, Pp n/a-n/a (2020) Physiological Reports |
| Popis: | Bone morphogenetic protein 4 (BMP4) plays an important role in bone remodeling and in heart failure pathogenesis. The aim of this study was to evaluate the effect of spontaneous physical activity on the expression of BMP4 in the heart and tibia of the transgenic (Tgαq*44) mice, representing a model of chronic heart failure. Tgαq*44 and wild‐type FVB mice (WT) were randomly assigned either to sedentary or to trained groups undergoing 8 weeks of spontaneous wheel running. The BMP4 protein expression in heart and tibiae was evaluated using Western immunoblotting and the phosphorus and calcium in the tibiae was assessed using the X‐ray microanalysis. BMP4 content in the hearts of the Tgαq*44‐sedentary mice was by ~490% higher than in the WT‐sedentary mice, whereas in tibiae the BMP4 content of the Tgαq*44‐sedentary mice was similar to that in the WT‐sedentary animals. Tgαq*44 mice revealed by ~28% poorer spontaneous physical activity than the WT mice. No effect of performed physical activity on the BMP4 content in the hearts of either in the Tgαq*44 or WT mice was observed. However, 8‐week spontaneous wheel running resulted in a decrease in the BMP4 expression in tibiae (by ~43%) in the group of Tgαq*44 mice only, with no changes in their bone phosphorus and calcium contents. We have concluded that prolonged period of spontaneous physical exercise does not increase the risk of the progression of the BMP4‐mediated pathological cardiac hypertrophy and does not affect bone mineral status in the chronic heart failure mice. This study shows that long‐lasting physical exercise does not increase the risk of the progression of the BMP4–mediated pathological cardiac hypertrophy. Moreover, assuming the pro‐inflammatory function of BMP4, training‐induced decrease in the BMP4 content in bone might have a slowing down impact on the progression of heart failure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|