Hypoglycemic Activity of a Series of α-Alkylthio and α-Alkoxy Carboxylic Acids Related to Ciglitazone
| Autor: | David Alan Clark, P. E. Genereux, E. M. Gibbs, Newton Ls, D. M. Lewis, Bernard Hulin |
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| Rok vydání: | 1996 |
| Předmět: |
Stereochemistry
Carboxylic acid Carboxylic Acids Mice Obese Ether Chemical synthesis Mice Structure-Activity Relationship chemistry.chemical_compound Stereospecificity Ciglitazone Drug Discovery Adipocytes Animals Hypoglycemic Agents Moiety Oxazoles Benzofurans chemistry.chemical_classification Molecular Structure Stereoisomerism 3T3 Cells Mice Mutant Strains Thiazoles Diabetes Mellitus Type 2 chemistry Alkoxy group Molecular Medicine Thiazolidinediones Enantiomer |
| Zdroj: | Journal of Medicinal Chemistry. 39:3897-3907 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | The thiazolidinedione moiety of ciglitazone and its analogues can be replaced by an alpha-alkoxy or alpha-thioether carboxylic acid group. The influence of the nature of the R group, the length of the connector to the aromatic backbone of the molecule, and the stereochemistry have been studied. The most potent compounds have glucose-lowering activity at doses as low as 0.01 mg/kg. |
| Databáze: | OpenAIRE |
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