Gut butyrate-producing organisms correlate to Placenta Specific 8 protein: Importance to colorectal cancer progression
| Autor: | Ming Hung Shen, Chih-Yi Liu, Chi Cheng Huang, Shung Haur Yang, Jiun‑Wen Guo, Chi Jung Huang, Shao Kuan Chen, Kang Wei Chang |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Colorectal cancer Cell Gut microbiota Butyrate Gut flora medicine.disease_cause Article Metastasis 03 medical and health sciences 0302 clinical medicine Medicine lcsh:Science (General) neoplasms ComputingMethodologies_COMPUTERGRAPHICS Placenta Specific 8 lcsh:R5-920 Multidisciplinary biology business.industry Cell growth biology.organism_classification medicine.disease Colorectal cancer progression digestive system diseases 030104 developmental biology medicine.anatomical_structure Butyricicoccus Centrosome 030220 oncology & carcinogenesis Cancer research lcsh:Medicine (General) business Carcinogenesis lcsh:Q1-390 |
| Zdroj: | Journal of Advanced Research Journal of Advanced Research, Vol 22, Iss, Pp 7-20 (2020) |
| ISSN: | 2090-1232 |
| Popis: | Graphical abstract Highlights • Genes from stools have molecular significance with CRC tumorgenesis. • SCFAs, the metabolites of microbiota, can suppress CRC tumorigenesis. • Relationship between colonic genes, gut microbiota, or their metabolites is significant. • Changes of PLAC8 and butyrate-producing organisms were found in stools of CRC patients. • Butyrate can reduce the CRC formation through regulating PLAC8 expression. Tumor metastasis or recurrence often occurs in patients with curative resection of colorectal cancer (CRC). Placental-specific 8 (PLAC8), which has increased expression in stool, may be associated with CRC recurrence. Insights into the role of PLAC8 in CRC recurrence and its clinical significance may support to develop strategies for preventing CRC recurrence and deterioration. Clinical tissues, cell and animal models were used to clarify the roles of PLAC8 in CRC tumorigenesis, invasion, and migration. Next-generation sequencing of 16S ribosomal DNA has been used to assess the gut microbiota in stool of CRC patients. We found that PLAC8 was upregulated in tissues from patients with late-stage CRC. In our in vitro studies, PLAC8 was dynamically regulated in mitotic cells. Overexpressed PLAC8 was nucleated at the centrosome during mitosis, and therefore, PLAC8 overexpression might increase cell growth and migration (all p |
| Databáze: | OpenAIRE |
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