Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram
| Autor: | Alessandro Stefano 1, Pietro Pisciotta 1, 2, Marco Pometti 3, 4, Albert Comelli 1, 5, Sebastiano Cosentino 4, Francesco Marletta 4, Salvatore Cicero 4, Maria G. Sabini 2, Massimo Ippolito 4, Giorgio Russo 1 |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
gamma knife
medicine.medical_treatment Standardized uptake value Gamma knife imaging quantification [11C]-methionine positron emission tomography cancer lcsh:Technology 030218 nuclear medicine & medical imaging lcsh:Chemistry 03 medical and health sciences 0302 clinical medicine Histogram medicine General Materials Science In patient lcsh:QH301-705.5 Instrumentation Fluid Flow and Transfer Processes medicine.diagnostic_test lcsh:T business.industry Process Chemistry and Technology General Engineering Area under the curve lcsh:QC1-999 Computer Science Applications Radiation therapy Functional imaging lcsh:Biology (General) lcsh:QD1-999 lcsh:TA1-2040 Positron emission tomography 030220 oncology & carcinogenesis lcsh:Engineering (General). Civil engineering (General) business Nuclear medicine lcsh:Physics |
| Zdroj: | Applied Sciences Volume 11 Issue 7 Applied sciences 11 (2021): 2999. doi:10.3390/app11072999 info:cnr-pdr/source/autori:Alessandro Stefano 1, Pietro Pisciotta 1,2, Marco Pometti 3,4, Albert Comelli 1,5, Sebastiano Cosentino 4, Francesco Marletta 4, Salvatore Cicero 4, Maria G. Sabini 2,4, Massimo Ippolito 4 and Giorgio Russo 1,2,4/titolo:Early Monitoring Response to Therapy in Patients with Brain Lesions Using the Cumulative SUV Histogram/doi:10.3390%2Fapp11072999/rivista:Applied sciences/anno:2021/pagina_da:2999/pagina_a:/intervallo_pagine:2999/volume:11 Applied Sciences, 11(7):2999, 1-12. MDPI AG Applied Sciences, Vol 11, Iss 2999, p 2999 (2021) |
| ISSN: | 2076-3417 |
| DOI: | 10.3390/app11072999 |
| Popis: | Featured ApplicationThe study proposes a methodology to evaluate the response of patients with brain lesions to Gamma Knife treatments through the use of Positron Emission Tomography imaging.Gamma Knife treatment is an alternative to traditional brain surgery and whole-brain radiation therapy for treating cancers that are inaccessible via conventional treatments. To assess the effectiveness of Gamma Knife treatments, functional imaging can play a crucial role. The aim of this study is to evaluate new prognostic indices to perform an early assessment of treatment response to therapy using positron emission tomography imaging. The parameters currently used in nuclear medicine assessments can be affected by statistical fluctuation errors and/or cannot provide information on tumor extension and heterogeneity. To overcome these limitations, the Cumulative standardized uptake value (SUV) Histogram (CSH) and Area Under the Curve (AUC) indices were evaluated to obtain additional information on treatment response. For this purpose, the absolute level of [11C]-Methionine (MET) uptake was measured and its heterogeneity distribution within lesions was evaluated by calculating the CSH and AUC indices. CSH and AUC parameters show good agreement with patient outcomes after Gamma Knife treatments. Furthermore, no relevant correlations were found between CSH and AUC indices and those usually used in the nuclear medicine environment. CSH and AUC indices could be a useful tool for assessing patient responses to therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|