MicroRNA-374a Expression as a Prognostic Biomarker in Lung Adenocarcinoma
| Autor: | Kim, Yeseul, Sim, Jongmin, Kim, Hyunsung, Bang, Seong Sik, Jee, Seungyun, Park, Sungeon, Jang, Kiseok |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Histology recurrence lung neoplasms Pathology and Forensic Medicine law.invention 03 medical and health sciences 0302 clinical medicine law Gene expression microRNA medicine lcsh:Pathology Stage (cooking) Lung cancer micrornas Polymerase chain reaction Survival analysis Lung adenocarcinoma business.industry medicine.disease stage 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research Adenocarcinoma Original Article business lcsh:RB1-214 |
| Zdroj: | Journal of Pathology and Translational Medicine, Vol 53, Iss 6, Pp 354-360 (2019) Journal of Pathology and Translational Medicine |
| ISSN: | 2383-7845 2383-7837 |
| Popis: | Background Lung cancer is the most common cause of cancer-related death, and adenocarcinoma is the most common histologic subtype. MicroRNA is a small non-coding RNA that inhibits multiple target gene expression at the post-transcriptional level and is commonly dysregulated in malignant tumors. The purpose of this study was to analyze the expression of microRNA-374a (miR-374a) in lung adenocarcinoma and correlate its expression with various clinicopathological characteristics. Methods The expression level of miR-374a was measured in 111 formalin-fixed paraffin-embedded lung adenocarcinoma tissues using reverse transcription-quantitative polymerase chain reaction assays. The correlation between miR-374a expression and clinicopathological parameters, including clinical outcome, was further analyzed. Results High miR-374 expression was correlated with advanced pT category (chi-square test, p=.004) and pleural invasion (chi-square test, p=.034). Survival analysis revealed that patients with high miR-374a expression had significantly shorter disease-free survival relative to those with low miR-374a expression (log-rank test, p=.032). Conclusions miR-374a expression may serve as a potential prognostic biomarker for predicting recurrence in early stage lung adenocarcinoma after curative surgery. |
| Databáze: | OpenAIRE |
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