Leisure-Time Physical Activity and Reduced Plasma Levels of Obesity-Related Inflammatory Markers
| Autor: | Eric B. Rimm, Tobias Pischon, Gökhan S. Hotamisligil, Nader Rifai, Susan E. Hankinson |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Leptin Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Medicine (miscellaneous) Inflammation Type 2 diabetes Receptors Tumor Necrosis Factor Body Mass Index Cohort Studies chemistry.chemical_compound Endocrinology Insulin resistance Internal medicine medicine Humans Insulin Obesity Prospective Studies Exercise Glycated Hemoglobin C-Peptide biology Interleukin-6 C-peptide business.industry C-reactive protein Public Health Environmental and Occupational Health Middle Aged medicine.disease C-Reactive Protein Cross-Sectional Studies chemistry biology.protein Female medicine.symptom business Biomarkers Food Science |
| Zdroj: | Obesity Research. 11:1055-1064 |
| ISSN: | 1071-7323 |
| Popis: | Objective: This study investigated the relationship between physical activity and the obesity-related inflammatory markers C-reactive protein, interleukin-6, and soluble tumor necrosis factor receptors (sTNF-Rs) 1 and 2. Furthermore, we examined the relationship between physical activity and insulin sensitivity (insulin, C-peptide, and hemoglobin A1c levels) and whether inflammatory markers mediate this association. Research Methods and Procedures: Biomarkers were measured in 405 healthy men and 454 healthy women from two large ongoing prospective studies. Information about physical activity and other variables was assessed by questionnaires. Results: After adjustment for other predictors of inflammation, physical activity was inversely associated with plasma levels of sTNF-R1, sTNF-R2, interleukin-6, and C-reactive protein (p = 0.07, p = 0.004, p = 0.04, and p = 0.009). After further adjustment for BMI and leptin, as a surrogate for fat mass, most of these associations were no longer significant. Physical activity was also inversely related to insulin and C-peptide levels (p = 0.008 and p < 0.001); however, in contrast to BMI and leptin, levels of inflammatory markers explained only very little of this inverse relationship. Discussion: These results suggest that frequent physical activity is associated with lower systemic inflammation and improved insulin sensitivity. These associations can partially be explained by a lower degree of obesity in physically active subjects. Although inflammatory markers may mediate obesity-dependent effects of physical activity on inflammatory related diseases such as type 2 diabetes or coronary heart disease, our study suggests that they do not directly account for the beneficial effects of physical activity on insulin resistance. |
| Databáze: | OpenAIRE |
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