Axonal swellings and spheroids: a new insight into the pathology of neurocysticercosis
| Autor: | Alan Mejia Maza, Danitza G Dávila-Villacorta, Manuela Verastegui, Hector H. Garcia, Cesar M. Gavidia, Javier Mamani, Gino Castillo, Emma S Carter, Armando E. Gonzalez, Robert H. Gilman, Joseph Alroy, Charles R. Sterling, Jemina D Morales, Randy Woltjer, Rogger P Carmen-Orozco |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
pig Pathology Swine Neurocysticercosis microglia nerve fiber degeneration amyloid precursor protein animal cell Rats Sprague-Dawley Pathogenesis Epilepsy brain tissue 0302 clinical medicine Taenia solium Amyloid precursor protein rat oncosphere brain disease General Neuroscience phagocyte Brain neurocysticercosis Pathophysiology medicine.drug_formulation_ingredient spheroid cell embryonic structures immunohistochemistry parenchyma meninx immunoreactivity medicine.medical_specialty Neurofilament animal experiment spheroids Biology neurofilament Article Pathology and Forensic Medicine animal tissue 03 medical and health sciences brain histology astrocyte Spheroids Cellular parasitic diseases medicine Animals Humans controlled study T. solium oncospheres human Letters to the Editor neuropathology nonhuman animal model purl.org/pe-repo/ocde/ford#3.01.04 [https] medicine.disease Axons human tissue Rats purl.org/pe-repo/ocde/ford#3.01.09 [https] 030104 developmental biology biology.protein Axoplasmic transport Neurology (clinical) APP 030217 neurology & neurosurgery |
| Zdroj: | Brain Pathol |
| Popis: | Neurocysticercosis is a parasitic brain disease caused by the larval form (Cysticercus cellulosae) of the Taenia solium and is the leading cause of preventable epilepsy world-wide. However, the pathophysiology and relation to the wide range of clinical features remains poorly understood. Axonal swelling is emerging as an important early pathological finding in multiple neurodegenerative diseases and causes of brain injury, but has not been well-described in neurocysticercosis. Histological analysis was performed on human, rat and porcine NCC brain specimens to identify axonal pathology. Rat infection was successfully carried out via two routes of inoculation: direct intracranial injection and oral feeding. Extensive axonal swellings, in the form of spheroids, were observed in both humans and rats and to a lesser extent in pigs with NCC. Spheroids demonstrated increased immunoreactivity to amyloid precursor protein and neurofilament indicating probable impairment of axonal transport. These novel findings demonstrate that spheroids are present in NCC which is conserved across species. Not only is this an important contribution towards understanding that pathogenesis of NCC, but it also provides a model to analyze the association of spheroids with specific clinical features and to investigate the reversibility of spheroid formation with antihelmintic treatment. |
| Databáze: | OpenAIRE |
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