Discovery of natural anti-inflammatory alkaloids: Potential leads for the drug discovery for the treatment of inflammation
| Autor: | Zhichao Zhong, Ziqiang Bai, Renren Bai, Xiang-Yang Ye, Jiamin Ge, Chuansheng Yao, Yuanyuan Xie, Tian Xie |
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| Rok vydání: | 2021 |
| Předmět: |
Drug
medicine.drug_class media_common.quotation_subject Anti-Inflammatory Agents Inflammation Bioinformatics 01 natural sciences Anti-inflammatory 03 medical and health sciences Alkaloids Immune system Drug Discovery medicine Animals Humans 030304 developmental biology media_common Pharmacology Biological Products 0303 health sciences Molecular Structure 010405 organic chemistry Drug discovery Chemistry Organic Chemistry General Medicine 0104 chemical sciences medicine.symptom |
| Zdroj: | European Journal of Medicinal Chemistry. 213:113165 |
| ISSN: | 0223-5234 |
| Popis: | Inflammation is an adaptive response of the immune system to tissue malfunction or homeostatic imbalance. Corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) are frequently applied to treat varieties of inflammatory diseases but are associated with gastrointestinal, cardiovascular, and kidney side effects. Developing more effective and less toxic agents remain a challenge for pharmaceutical chemist due to the complexity of the different inflammatory processes. Alkaloids are widely distributed in plants with diverse anti-inflammatory activities, providing various potential lead compounds or candidates for the design and discovery of new anti-inflammatory drug candidates. Therefore, re-examining the anti-inflammatory alkaloid natural products is advisable, bringing more opportunities. In this review, we summarized and described the recent advances of natural alkaloids with anti-inflammatory activities and possible mechanisms in the period from 2009 to 2020. It is hoped that this review of anti-inflammatory alkaloids can provide new ideas for researchers engaged in the related fields and potential lead compounds for the discovery of anti-inflammatory drugs. |
| Databáze: | OpenAIRE |
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