Some effects of dieldrin and mirex on Ehrlich ascites tumor cellsin vivo andin vitro
| Autor: | Gale Gr, Richard H. Gadsden, Ernest M. Walker, Loretta M. Atkins |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Insecticides Health Toxicology and Mutagenesis In Vitro Techniques Toxicology Ehrlich ascites Mice Dieldrin chemistry.chemical_compound Animals RNA Neoplasm Carcinoma Ehrlich Tumor Mirex Purine metabolism Mice Inbred BALB C RNA DNA Neoplasm General Medicine Pollution In vitro Uridine Neoplasm Proteins chemistry Biochemistry Purines Thymidine DNA |
| Zdroj: | Archives of Environmental Contamination and Toxicology. 5:333-341 |
| ISSN: | 1432-0703 0090-4341 |
| DOI: | 10.1007/bf02220915 |
| Popis: | The effects of dieldrin and mirex on Ehrlich ascites tumor cells were assessed, using certain in vivo (in mice) and in vitro measurements. Mirex retarded the development of Ehrlich ascites tumor in vivo, but dieldrin did not. Effects of dieldrin on de nova RNA purine synthesis from formate in vivo were slight, while mirex inhibited the synthesis of both RNA purines. Dieldrin inhibited the in vitro incorporation if thymidine, uridine, and L-leucine into DNA, RNA, and protein, respectively, but mirex was virtually without effect. |
| Databáze: | OpenAIRE |
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