Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk

Autor: Amy Miles, Martin Preisig, Yuliya S. Nikolova, Jianxin Shi, Mark Adams, Fernanda Caroline dos Santos, Glyn Lewis, Rudolf Uher, Lisa Jones, Brenda W.J.H. Penninx, Etienne Sibille, Roy H. Perlis, Cathryn M. Lewis, Andrew M. McIntosh, James B. Potash, Myrna M. Weissman, Ahmad R. Hariri, Bernhard T. Baune, Jordan W. Smoller, Miguel E. Rentería, Dorret I. Boomsma, Giorgio Pistis, Enda M. Byrne, Steven P. Hamilton, Douglas F. Levinson, Enrique Castelao, Ian Jones, K Oliver Schubert
Přispěvatelé: Biological Psychology, APH - Mental Health, APH - Methodology, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, APH - Digital Health
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Miles, A E, Dos Santos, F C, Byrne, E M, Renteria, M E, McIntosh, A M, Adams, M J, Pistis, G, Castelao, E, Preisig, M, Baune, B T, Schubert, K O, Lewis, C M, Jones, L A, Jones, I, Uher, R, Smoller, J W, Perlis, R H, Levinson, D F, Potash, J B, Weissman, M M, Shi, J, Lewis, G, Penninx, B W J H, Boomsma, D I, Hamilton, S P, Sibille, E, Hariri, A R, Nikolova, Y S & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2021, ' Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk ', Neuropsychopharmacology, vol. 46, no. 13, pp. 2304-2311 . https://doi.org/10.1038/s41386-021-01189-x
Neuropsychopharmacology, 46(13), 2304-2311. Nature Publishing Group
Miles, A E, Dos Santos, F C, Byrne, E M, Renteria, M E, Mcintosh, A M, Adams, M J, Pistis, G, Castelao, E, Preisig, M, Baune, B T, Schubert, K O, Lewis, C M, Jones, L A, Jones, I, Uher, R, Smoller, J W, Perlis, R H, Levinson, D F, Potash, J B, Weissman, M M, Shi, J, Lewis, G, Penninx, B W J H, Boomsma, D I, Hamilton, S P, Sibille, E, Hariri, A R & Nikolova, Y S 2021, ' Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk ', Neuropsychopharmacology . https://doi.org/10.1038/s41386-021-01189-x
Neuropsychopharmacology
Print: 0893-133X
Miles, A E, Boomsma, D I, Nikolova, Y S & Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2021, ' Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk ', Neuropsychopharmacology, vol. 46, no. 13, pp. 2304-2311 . https://doi.org/10.1038/s41386-021-01189-x
Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 2021, ' Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk ', Neuropsychopharmacology, vol. 46, no. 13, pp. 2304-2311 . https://doi.org/10.1038/s41386-021-01189-x
ISSN: 0893-133X
1740-634X
DOI: 10.1038/s41386-021-01189-x
Popis: Studies in post-mortem human brain tissue have associated major depressive disorder (MDD) with cortical transcriptomic changes, whose potential in vivo impact remains unexplored. To address this translational gap, we recently developed a transcriptome-based polygenic risk score (T-PRS) based on common functional variants capturing ‘depression-like’ shifts in cortical gene expression. Here, we used a non-clinical sample of young adults (n = 482, Duke Neurogenetics Study: 53% women; aged 19.8 ± 1.2 years) to map T-PRS onto brain morphology measures, including Freesurfer-derived subcortical volume, cortical thickness, surface area, and local gyrification index, as well as broad MDD risk, indexed by self-reported family history of depression. We conducted side-by-side comparisons with a PRS independently derived from a Psychiatric Genomics Consortium (PGC) MDD GWAS (PGC-PRS), and sought to link T-PRS with diagnosis and symptom severity directly in PGC-MDD participants (n = 29,340, 59% women; 12,923 MDD cases, 16,417 controls). T-PRS was associated with smaller amygdala volume in women (t = −3.478, p = 0.001) and lower prefrontal gyrification across sexes. In men, T-PRS was associated with hypergyrification in temporal and occipital regions. Prefrontal hypogyrification mediated a male-specific indirect link between T-PRS and familial depression (b = 0.005, p = 0.029). PGC-PRS was similarly associated with lower amygdala volume and cortical gyrification; however, both effects were male-specific and hypogyrification emerged in distinct parietal and temporo-occipital regions, unassociated with familial depression. In PGC-MDD, T-PRS did not predict diagnosis (OR = 1.007, 95% CI = [0.997–1.018]) but correlated with symptom severity in men (rho = 0.175, p = 7.957 × 10−4) in one cohort (N = 762, 48% men). Depression-like shifts in cortical gene expression have sex-specific effects on brain morphology and may contribute to broad depression vulnerability in men.
Databáze: OpenAIRE
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