A cluster of fulminant, fatal necrotizing community-associated methicillin-resistant Staphylococcus aureus pneumonias
| Autor: | Larry Lambert, Robert McCabe, Colin Feeney, Aparajita Sohoni |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Methicillin-Resistant Staphylococcus aureus medicine.drug_class Fulminant Antibiotics Bacterial Toxins Leukocidin Exotoxins Critical Care Nursing medicine.disease_cause Microbiology Leukocidins Pneumonia Staphylococcal medicine Humans business.industry General Medicine biochemical phenomena metabolism and nutrition Middle Aged bacterial infections and mycoses medicine.disease Methicillin-resistant Staphylococcus aureus Anti-Bacterial Agents Community-Acquired Infections Pneumonia Staphylococcus aureus Sputum Female Panton–Valentine leukocidin medicine.symptom business |
| Zdroj: | American journal of critical care : an official publication, American Association of Critical-Care Nurses. 22(4) |
| ISSN: | 1937-710X |
| Popis: | Community-associated methicillin-resistant Staphylococcus aureus is a frequent cause of skin and soft-tissue infections and is increasingly identified as a cause of pneumonia in immunocompetent patients. Panton-Valentine leukocidin, one of several leukocytotoxic peptides secreted by these cocci, is associated with increased virulence. A cluster of 3 unrelated patients with fatal pneumonia presumably caused by community-associated methicillin-resistant S aureus positive for Panton-Valentine leukocidin were treated in a 3-week period. Despite aggressive care and appropriate, timely administration of antibiotics, all 3 patients died. This article reviews the clinical and laboratory features suggestive of this lethal isolate, including unique findings on Gram stains of sputum. |
| Databáze: | OpenAIRE |
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