4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists

Autor:	Marie-Paule Heitz, Alexander Alanine, Gerhard Trube, Ramanjit Gill, Vincent Mutel, Bernd Buettelmann, Rene Wyler, Anne Bourson, Emmanuel Pinard
Rok vydání:	2003
Předmět:	Stereochemistry Pyridines Clinical Biochemistry Pharmaceutical Science Biochemistry Chemical synthesis Receptors N-Methyl-D-Aspartate Mice Structure-Activity Relationship In vivo Seizures Drug Discovery Structure–activity relationship Animals Molecular Biology Bicyclic molecule Chemistry Organic Chemistry Glutamate receptor Antagonist General Medicine Muscarinic acetylcholine receptor M1 Subtype selective nervous system Quinolines Molecular Medicine NMDA receptor
Zdroj:	Bioorganicmedicinal chemistry letters. 13(10)
ISSN:	0960-894X
Popis:	A series of 4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and analogous quinolines was prepared and evaluated as NR1/2B subtype selective NMDA receptor antagonists. 2-Hydroxyalkylamino substitution combines high affinity with selectivity (vs alpha1 and M1 receptors) and activity in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd563b7a089446aaf6df93059daa0f5 https://pubmed.ncbi.nlm.nih.gov/12729659 Zobrazit plný text záznamu Full Text from ScienceDirect