Hyperuricemia prevalence in healthy subjects and its relationship with cardiovascular target organ damage
Autor: | Michele Bombelli, Giovanni Tavecchia, Esmerilda Qualliu, Cristina Giannattasio, Guido Grassi, Lucia Occhi, Enzo Grasso, Stefano Signorini, Martina Milani, Sun Jinwei, P. Vallerio, Alessandro Maloberti, Marco Casati, Paolo Brambilla, Iside Cartella, Chiara Tognola |
---|---|
Přispěvatelé: | Maloberti, A, Qualliu, E, Occhi, L, Jinwei, S, Grasso, E, Tognola, C, Tavecchia, G, Cartella, I, Milani, M, Vallerio, P, Signorini, S, Brambilla, P, Casati, M, Bombelli, M, Grassi, G, Giannattasio, C |
Rok vydání: | 2021 |
Předmět: |
Male
Multivariate statistics Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030204 cardiovascular system & hematology Correlation chemistry.chemical_compound 0302 clinical medicine Risk Factors Prevalence Hyperuricemia Pulse wave velocity Aged 80 and over education.field_of_study Nutrition and Dietetics Middle Aged Healthy Volunteers Italy Cardiovascular Diseases Cardiology Female Kidney Diseases Glomerular filtration rate Cardiology and Cardiovascular Medicine Healthy subject Adult medicine.medical_specialty Adolescent Population Renal function 030209 endocrinology & metabolism Risk Assessment Young Adult 03 medical and health sciences Internal medicine Linear regression medicine Humans education Aged Target organ damage business.industry medicine.disease Cross-Sectional Studies chemistry Uric acid business Biomarkers |
Zdroj: | Nutrition, Metabolism and Cardiovascular Diseases. 31:178-185 |
ISSN: | 0939-4753 |
Popis: | Background and aim Heterogeneous results have been obtained in the relationship between Uric Acid (UA) and Target Organ Damage (TOD). In the present study we sought to assess the prevalence of hyperuricemia in healthy subjects as well as the role of UA in determining TOD. We evaluated vascular, cardiac and renal TODs in the whole population as well as sub-grouped by gender. Methods and results As many as 379 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Mass Index (LVMI) and carotid Intima-Media Thickness (IMT). Hyperuricemia was defined with the classic cut-off (>7.0 in men and >6.0 mg/dL in women) but also with a most recently defined one (5.6 mg/dL for both sex). Hyperuricemia was present in 6.3% of the whole population (7.3% males, 2.8% females) considering the classic cut-off, while, with the recently identified one, it was present in 28.2% of the whole population (37.3% males, 4.7% females). Despite all the evaluated TODs significantly correlated with UA, linear multivariate regression analysis showed that none of them, except for GFR, displayed UA as a significant covariate. Similar figures were found also when both correlation and linear regression analyses were repeated in the two genders separately. Conclusions Hyperuricemia is an important problem also in healthy subjects and its prevalence could further increase if lower cut-off will be used. In this specific population UA is significantly associated with renal impairment while this was not the case for cardiac and vascular damage. |
Databáze: | OpenAIRE |
Externí odkaz: |