Hyperuricemia prevalence in healthy subjects and its relationship with cardiovascular target organ damage

Autor: Michele Bombelli, Giovanni Tavecchia, Esmerilda Qualliu, Cristina Giannattasio, Guido Grassi, Lucia Occhi, Enzo Grasso, Stefano Signorini, Martina Milani, Sun Jinwei, P. Vallerio, Alessandro Maloberti, Marco Casati, Paolo Brambilla, Iside Cartella, Chiara Tognola
Přispěvatelé: Maloberti, A, Qualliu, E, Occhi, L, Jinwei, S, Grasso, E, Tognola, C, Tavecchia, G, Cartella, I, Milani, M, Vallerio, P, Signorini, S, Brambilla, P, Casati, M, Bombelli, M, Grassi, G, Giannattasio, C
Rok vydání: 2021
Předmět:
Male
Multivariate statistics
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
030204 cardiovascular system & hematology
Correlation
chemistry.chemical_compound
0302 clinical medicine
Risk Factors
Prevalence
Hyperuricemia
Pulse wave velocity
Aged
80 and over
education.field_of_study
Nutrition and Dietetics
Middle Aged
Healthy Volunteers
Italy
Cardiovascular Diseases
Cardiology
Female
Kidney Diseases
Glomerular filtration rate
Cardiology and Cardiovascular Medicine
Healthy subject
Adult
medicine.medical_specialty
Adolescent
Population
Renal function
030209 endocrinology & metabolism
Risk Assessment
Young Adult
03 medical and health sciences
Internal medicine
Linear regression
medicine
Humans
education
Aged
Target organ damage
business.industry
medicine.disease
Cross-Sectional Studies
chemistry
Uric acid
business
Biomarkers
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases. 31:178-185
ISSN: 0939-4753
Popis: Background and aim Heterogeneous results have been obtained in the relationship between Uric Acid (UA) and Target Organ Damage (TOD). In the present study we sought to assess the prevalence of hyperuricemia in healthy subjects as well as the role of UA in determining TOD. We evaluated vascular, cardiac and renal TODs in the whole population as well as sub-grouped by gender. Methods and results As many as 379 blood donors participated at the present analysis. TOD was evaluated as Pulse Wave Velocity (PWV), Left Ventricular Mass Index (LVMI) and carotid Intima-Media Thickness (IMT). Hyperuricemia was defined with the classic cut-off (>7.0 in men and >6.0 mg/dL in women) but also with a most recently defined one (5.6 mg/dL for both sex). Hyperuricemia was present in 6.3% of the whole population (7.3% males, 2.8% females) considering the classic cut-off, while, with the recently identified one, it was present in 28.2% of the whole population (37.3% males, 4.7% females). Despite all the evaluated TODs significantly correlated with UA, linear multivariate regression analysis showed that none of them, except for GFR, displayed UA as a significant covariate. Similar figures were found also when both correlation and linear regression analyses were repeated in the two genders separately. Conclusions Hyperuricemia is an important problem also in healthy subjects and its prevalence could further increase if lower cut-off will be used. In this specific population UA is significantly associated with renal impairment while this was not the case for cardiac and vascular damage.
Databáze: OpenAIRE
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