Efficient and environmentally sustainable domino protocol for the synthesis of diversified spiroheterocycles with privileged heterocyclic substructures using bio-organic catalyst in aqueous medium
| Autor: | Kanchan Verma, Mahendra Kumar, Yogesh Kumar Tailor, Sarita Khandelwal, Esha Rushell, Monu Agarwal |
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| Rok vydání: | 2019 |
| Předmět: |
Taurine
Chemistry Pharmaceutical Hydantoin Structural diversity 010402 general chemistry 01 natural sciences Catalysis Domino Inorganic Chemistry chemistry.chemical_compound Heterocyclic Compounds Drug Discovery Amino Acids Physical and Theoretical Chemistry Molecular Biology Protocol (object-oriented programming) Reusability Aqueous medium 010405 organic chemistry Drug discovery Chemistry Organic Chemistry Imidazoles Water General Medicine Combinatorial chemistry 0104 chemical sciences Information Systems |
| Zdroj: | Molecular Diversity. 24:1355-1365 |
| ISSN: | 1573-501X 1381-1991 |
| Popis: | An efficient and environmentally sustainable synthetic protocol has been presented to synthesize structurally diverse spiroxindoles spiroannulated with indenopyrroloimidazoles, pyranopyrroloimidazoles, chromenopyrroloimidazoles, and imidazopyrrolopyrimidines involving three-component reaction of isatins, hydantoin, and β-diketones in the presence of green and sustainable bio-organic catalyst, β-amino acid, 2-aminoethanesulfonic acid (taurine), in aqueous media. The synthetic efficiency, operational simplicity, and reusability of catalyst make the present synthetic protocol cost effective, time efficient, and eco-friendly to synthesize molecules with structural diversity and molecular complexity and expected to contribute significantly not only to drug discovery research but also to pharmaceutical and medicinal chemistry. |
| Databáze: | OpenAIRE |
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