Nanoformulations with synthetic and plant-derived compounds for cattle tick control

Autor: Amanda Figueiredo, Luís Adriano Anholeto, Diego Faria Cola, Rafaela Regina Fantatto, Isabella Barbosa Santos, Yousmel Alemán Gainza, Gustavo Avelar Sousa, Laura Jane Pickett, Leonardo Fernandes Fraceto, Ana Carolina de Souza Chagas
Rok vydání: 2022
Předmět:
Zdroj: Veterinary Parasitology. 309:109756
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2022.109756
Popis: Nanocarriers of acaricidal compounds improve the bioavailability, absorption, and tissue distribution of active ingredients, releasing them in a slow, targeted way and protecting them against premature degradation. Thus, this study aimed to develop formulations from solid lipid nanoparticles (SLN), or nanostructured lipid carriers (NLC) associated with cypermethrin (cip) + chlorpyrifos (chlo) and vegetable compounds (citral, menthol, or limonene). Particles were then characterised, and their efficacy was verified on R. microplus in comparison to nanoformulations without the plant-based compounds. Six different formulations were developed and characterised by dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA). Formulations 1 (SLN+cyp+chlo+citral), 2 (SLN+cyp+chlo+menthol), 3 (SLN+cyp+chlo+limonene), 4 (NLC+cyp+chlo+citral), 5 (NLC+cyp+chlo+menthol) and 6 (NLC+cyp+chlo+limonene) had mean diameters from 286 to 304 nm; polydispersion from 0.16 to 0.18; zeta potential from -15.8 to -20 mV, concentration from 3.37 ± 0.24 × 10
Databáze: OpenAIRE
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