Clinically significant extra-cardiac findings in asymptomatic HIV-positive men undergoing cardiac magnetic resonance imaging
| Autor: | Caroline Daly, Aisling Loy, R Morgan, Siobhan O’Dea, Fiona Mulcahy |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Magnetic Resonance Imaging Cine HIV Infections Dermatology Logistic regression Sensitivity and Specificity Acquired immunodeficiency syndrome (AIDS) Cardiac magnetic resonance imaging Predictive Value of Tests Risk Factors Internal medicine medicine Prevalence Humans Pharmacology (medical) Asymptomatic HIV Subclinical infection Incidental Findings medicine.diagnostic_test business.industry Incidentaloma Public Health Environmental and Occupational Health Magnetic resonance imaging Heart Middle Aged medicine.disease Infectious Diseases Anti-Retroviral Agents Radiological weapon Case-Control Studies Regression Analysis Female Radiology business |
| Zdroj: | International journal of STDAIDS. 26(5) |
| ISSN: | 1758-1052 |
| Popis: | Increased research-based imaging has led to an increase in clinically significant extra-cardiac findings. HIV patients are at increased risk of having polypathology at a younger age; therefore, it may be hypothesised that they would have more incidental findings on imaging. We reviewed the magnetic resonance imaging results of 169 HIV-positive and 40 HIV-negative, clinically well volunteers undergoing cardiac magnetic resonance imaging scanning to assess the prevalence of subclinical cardiac pathology. This sub-study assessed the prevalence of clinically significant extra-cardiac findings. Associated risk factors were assessed and clinical follow-up and outcome were ascertained. Of the HIV-positive study group, 12/169 (7.1%) vs. 1/40 (2.5%) control patients had a clinically significant extra-cardiac finding which warranted further radiological or clinical intervention ( p = 0.28). A total of three out of 169 (1.1%) were highly clinically significant findings. On logistic regression analysis, age was the only significant contributing factor ( p = 0.049); no HIV-associated factors were found to be significant. The prevalence of clinically significant extra-cardiac findings of 7.1% in this HIV-positive cohort is comparable to the prevalence found in previous studies carried out on an older, sicker general population. This highlights the need for planning for unexpected outcomes and also the high rate of clinically significant findings in a seemingly well HIV-positive population. |
| Databáze: | OpenAIRE |
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