Design and Fabrication of a Magnetite-based Polymer-supported Hybrid Nanocomposite: A Promising Heterogeneous Catalytic System Utilized in Known Palladium-assisted Coupling Reactions
| Autor: | Reza Taheri-Ledari, Reza Ghalavand, Ali Maleki |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Polymers Surface Properties Magnetic separation chemistry.chemical_element 02 engineering and technology 010402 general chemistry 01 natural sciences Coupling reaction Catalysis Nanocomposites Suzuki reaction Coordination Complexes Drug Discovery Particle Size Magnetite Nanoparticles Reusability Nanocomposite Molecular Structure Organic Chemistry General Medicine 021001 nanoscience & nanotechnology 0104 chemical sciences Computer Science Applications Chemical engineering chemistry Reagent Drug Design 0210 nano-technology Palladium |
| Zdroj: | Combinatorial chemistryhigh throughput screening. 23(2) |
| ISSN: | 1875-5402 |
| Popis: | Objective: Herein, a novel heterogeneous catalytic system constructed of iron oxide and palladium nanoparticles is presented. Firstly, a convenient synthetic pathway for the preparation of this catalytic system is introduced, then the application of the fabricated nanocomposite in the Pd-catalyzed C─C coupling reactions is monitored. High reaction yields (98%) have been obtained in short reaction time, by using this catalytic system. Materials and Methods: Fe3O4/P4VP-Pd catalytic system was fabricated via an in situ method by 4- vinylpyridine (4-VP). In this regard, all the essential structural analyses such as FT-IR, EDX, VSM, and TGA have been performed on the Fe3O4/P4VP-Pd catalytic system to investigate its properties. The spherical morphology of the NPs and their uniform size have also been studied by the SEM method. Further, the reaction progress was controlled by thin-layer chromatography. Finally, NMR analysis was used to identify the synthesized biphenyl pharmaceutical derivatives. Results: High efficiency of this catalytic system has been precisely investigated and the optimal conditions were determined. The catalytic process is carried out in 20 min, under mild conditions (room temperature). Then, the purification process is easily performed via magnetic separation of the catalyst NPs. After completion of the synthesis reaction, the NPs were collected, washed, and reused several times. Conclusion: Among recently reported heterogeneous catalytic systems, Fe3O4/P4VP-Pd is recommended due to its high catalytic performance, convenience of the preparation process, excellent biocompatibility, economic benefits, and well reusability. Overall, in order to save time in the complex synthetic processes and also prevent using so many chemical reagents and solvents for the purification process, the presented catalytic system could be suitable for scaling up and applying for the industrial applications. |
| Databáze: | OpenAIRE |
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