Role of mannose-binding lectin-2 polymorphism in the development of acute cellular rejection after transplantation for hepatitis C virus-induced liver disease
| Autor: | Sabine Boas-Knoop, Gero Puhl, Rajan Somasundaram, Ali Yahyazadeh, Peter Neuhaus, M Bahra, Dennis Eurich, U. Neumann, Martin Ruehl, Ruth Neuhaus |
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| Rok vydání: | 2011 |
| Předmět: |
Graft Rejection
Liver Cirrhosis Male Hepatitis C virus medicine.medical_treatment Disease Hepacivirus Liver transplantation medicine.disease_cause Mannose-Binding Lectin Liver disease Sex Factors Fibrosis Genotype medicine Humans Mannan-binding lectin Transplantation Polymorphism Genetic business.industry Incidence Liver Diseases bacterial infections and mycoses medicine.disease Hepatitis C Liver Transplantation Infectious Diseases Immunology Female business |
| Zdroj: | Transplant infectious disease : an official journal of the Transplantation Society. 14(5) |
| ISSN: | 1399-3062 |
| Popis: | The development of liver and graft disease is suspected to be affected by genetic diversity. Mannose-binding lectin-2 (MBL-2) is an important immunomodulatory factor that is involved in complement activation. The aim of our study was to elucidate the role of MBL-2 genotypes after liver transplantation (LT) for hepatitis C virus (HCV)-induced liver disease regarding the incidence of acute cellular rejection (ACR), graft inflammation, fibrosis development, and antiviral treatment response. Methods A group of 149 patients who underwent LT for HCV-induced liver disease were genotyped for MBL-2 (rs7096206; G/C) by TaqMan genotyping assay. We evaluated 518 post-LT protocol biopsies and at least 98 urgent liver biopsies regarding graft fibrosis stages, inflammation grades, and evidence for rejection within MBL-2 genotype groups. Result No association of MBL-2 polymorphisms was observed regarding inflammation, fibrosis, and antiviral treatment outcome. However, the C allele of the MBL-2 gene (P = 0.001) and gender compatibility (P = 0.012) were factors significantly associated with the incidence of ACR. Conclusion MBL-2 polymorphisms and gender are involved in the development of ACR after LT. CC genotype and gender match may be regarded as risk factors for ACR in HCV-positive graft recipients. Further studies are needed to confirm and verify this observation in non-HCV groups as well. |
| Databáze: | OpenAIRE |
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