Premorbid Determinants of Left Ventricular Dysfunction in a Novel Model of Gradually Induced Pressure Overload in the Adult Canine
| Autor: | M. Michael Swindle, Masayoshi Hamawaki, George B. Keech, Masayoshi Nagatsu, George Cooper, Gilberto DeFreyte, Blase A. Carabello, Masaaki Koide, Hirofumi Tagawa, Michael R. Zile |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Heart disease Hemodynamics Ventricular Function Left Muscle hypertrophy Ventricular Dysfunction Left Dogs Physiology (medical) Internal medicine medicine.artery medicine Carnivora Animals Prospective Studies Retrospective Studies Pressure overload Aorta business.industry Reproducibility of Results medicine.disease Myocardial Contraction medicine.anatomical_structure Endocrinology Ventricle Heart failure Hypertension Female Hypertrophy Left Ventricular Stress Mechanical Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation. 95:1601-1610 |
| ISSN: | 1524-4539 0009-7322 |
| Popis: | Background When a pressure overload is placed on the left ventricle, some patients develop relatively modest hypertrophy whereas others develop extensive hypertrophy. Likewise, the occurrence of contractile dysfunction also is variable. The cause of this heterogeneity is not well understood. Methods and Results We recently developed a model of gradual proximal aortic constriction in the adult canine that mimicked the heterogeneity of the hypertrophic response seen in humans. We hypothesized that differences in outcome were related to differences present before banding. Fifteen animals were studied initially. Ten developed left ventricular dysfunction (dys group). Five dogs maintained normal function (nl group). At baseline, the nl group had a lower mean systolic wall stress (96±9 kdyne/cm 2 ; dys group, 156±7 kdyne/cm 2 ; P P 2 . Eighteen of 20 dogs with baseline mean systolic stress >115 kdyne/cm 2 developed dysfunction whereas 6 of 8 dogs with resting stress ≤115 kdyne/cm 2 maintained normal function. Conclusions We conclude that this canine model mimicked the heterogeneous hypertrophic response seen in humans. In the group that eventually developed dysfunction there was less cardiac mass despite 60% higher wall stress at baseline, suggesting a different set point for regulating myocardial growth in the two groups. |
| Databáze: | OpenAIRE |
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