Evaluation of pleural CYFRA 21-1 and carcinoembryonic antigen in the diagnosis of malignant pleural effusions
| Autor: | Mauduyt Ma, Gilles Salama, Guy Serre, P Rouzaud, P Carles, M C Pujazon, Christian Vincent, Marcel Miedougé |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent Pleural effusion Sensitivity and Specificity Pleural disease Cytokeratin Carcinoembryonic antigen Antigens Neoplasm Neoplasms Cytology Biomarkers Tumor medicine Humans Child CYFRA 21-1 Aged Retrospective Studies Aged 80 and over Keratin-19 biology business.industry Respiratory disease Middle Aged medicine.disease Carcinoembryonic Antigen Pleural Effusion Oncology biology.protein Keratins Female business Oncofetal antigen Research Article |
| Zdroj: | British Journal of Cancer |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1998.75 |
| Popis: | CYFRA 21-1 assay, measuring cytokeratin 19 fragments, was compared with carcinoembryonic antigen (CEA) assay, as an addition to cytological analysis for the diagnosis of malignant effusions. Both markers were determined with commercial enzyme immunoassays in pleural fluid from 196 patients. Cytological analysis and/or pleural biopsy confirmed the malignant origin of the effusion in 99 patients (76 carcinomas, nine pleural mesotheliomas and 14 non-epithelial malignancies). Effusions were confirmed as benign in 97 patients (33 cardiac failures, 39 infectious diseases--including 12 tuberculosis-- and 25 miscellaneous effusions). Both markers were significantly higher in malignant than in benign effusions. All the patients with non-epithelial malignancies presented CYFRA and CEA values lower than the 95% diagnostic specificity thresholds (100 and 6 ng ml(-1) respectively). The diagnostic sensitivity in the group of carcinomas and mesotheliomas was similar for CYFRA (58.8%) and CEA (64.7%). However, CEA had a significantly higher sensitivity in carcinomas (72.4% vs 55.3%), while CYFRA had a clearly higher sensitivity in mesotheliomas (89.9% vs 0%). Interestingly, 12 out of the 16 malignant effusions with a negative cytology were CEA and/or CYFRA positive. Regarding their high diagnostic sensitivity and their complementarity, CEA and CYFRA appear to be very useful for the diagnosis of malignant pleural effusions when cytology is negative. Images Figure 1 |
| Databáze: | OpenAIRE |
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