Effects of administration of cationic and native homologous albumin on the kidney
| Autor: | Coimbra Tm, Lachat Jj, Furtado Mr, de Carvalho If |
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| Rok vydání: | 1983 |
| Předmět: |
Anions
medicine.medical_specialty Chemical Phenomena Urinary system Kidney Glomerulus Lumen (anatomy) Urine Vacuole Kidney Kidney Tubules Proximal Internal medicine Albumins Cations medicine Animals Proteinuria business.industry Albumin Rats Inbred Strains Rats Chemistry Microscopy Electron medicine.anatomical_structure Endocrinology Renal physiology Creatinine Female medicine.symptom business Lysosomes |
| Zdroj: | Nephron. 33(3) |
| ISSN: | 1660-8151 |
| Popis: | Different doses of anionic and cationic albumin (CA) were administered intravenously to 29 normal unanesthetized female rats. Administration of 20 and 30 mg of CA produced an increase in urinary excretion of endogenous albumin. Urinary CA levels in the urine samples collected during the first 60 min after injection of 30 mg of CA were higher than anionic albumin levels. A marked increase in the number of endocytic vacuoles, large numbers of images suggesting fusion of vacuoles with lysosomes, extrusion of cell elements into the tubular lumen and tubule rupture were observed in the animals injected with CA. These results show that CA may produce changes in proteinuria and in renal structure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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