Effect of postnatal exposure to caffeine on the pattern of adenosine A1 receptor distribution in respiration-related nuclei of the rat brainstem
| Autor: | Rosario Pásaro, A. Frugière, F. Saadani-Makki, L. Bodineau, Susana P. Gaytán, Nicole Larnicol |
|---|---|
| Přispěvatelé: | Pediatric Critical Care Department, Children's Hospital of Michigan, Children's Hospital of Michigan, Dysrégulations Métaboliques Acquises et Génétiques. Approches moléculaires, physiologiques et neurobiologiques - EA UPJV 3901 (EA3901), Université de Picardie Jules Verne (UPJV)-Centre National de la Recherche Scientifique (CNRS), Neuropeptides centraux et régulations hydrique et cardiovasculaire, Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche en neurobiologie - neurophysiologie de Marseille (CRN2M), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Dysrégulations Métaboliques Acquises et Génétiques. Approches moléculaires, physiologiques et neurobiologiques, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre interdisciplinaire de recherche en biologie (CIRB), École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS Paris), Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Labex MemoLife, Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Male
MESH: Rats Sprague-Dawley MESH: Animals Newborn MESH: Caffeine Rats Sprague-Dawley chemistry.chemical_compound 0302 clinical medicine MESH: Pregnancy Pregnancy MESH: Gene Expression Regulation Developmental MESH: Animals 0303 health sciences Respiration Age Factors Gene Expression Regulation Developmental 3. Good health medicine.anatomical_structure Female Brainstem Caffeine medicine.drug medicine.medical_specialty MESH: Rats Central nervous system Adenosinergic Biology MESH: Receptor Adenosine A1 MESH: Central Nervous System Stimulants 03 medical and health sciences Cellular and Molecular Neuroscience Adenosine A1 receptor Internal medicine medicine Animals [SDV.BBM.BC]Life Sciences [q-bio]/Biochemistry Molecular Biology/Biochemistry [q-bio.BM] 030304 developmental biology MESH: Age Factors MESH: Respiration Receptor Adenosine A1 Endocrine and Autonomic Systems Adenosine Pons MESH: Male Rats Autonomic nervous system Endocrinology Animals Newborn chemistry MESH: Brain Stem Central Nervous System Stimulants Neurology (clinical) MESH: Female 030217 neurology & neurosurgery Brain Stem |
| Zdroj: | Autonomic Neuroscience: Basic and Clinical Autonomic Neuroscience: Basic and Clinical, 2006, 126-127, pp.339-46. ⟨10.1016/j.autneu.2006.03.009⟩ Autonomic Neuroscience: Basic and Clinical, Elsevier, 2006, 126-127, pp.339-46. ⟨10.1016/j.autneu.2006.03.009⟩ |
| ISSN: | 1566-0702 1872-7484 |
| DOI: | 10.1016/j.autneu.2006.03.009⟩ |
| Popis: | Caffeine, which belongs to the methylxantine family of compounds, is commonly ingested in a range of beverages such as coffee, tea, and cola drinks. It is also used therapeutically and is frequently employed in the treatment of respiratory disturbances in human neonates. The aim of the present work has been to examine the ontogeny of the adenosine A1 receptor system in the brainstem of the newborn rat following postnatal treatment with caffeine to mimic the therapeutic administration of caffeine to premature human infants. The effect of this postnatal exposure to caffeine on the gradual appearance of adenosine A1 receptors was analysed by determining immunohistochemically the distribution of the receptors. The main difference between control animals and animals exposed to caffeine was the transient increase (only at postnatal day 6) in the number of immunopositive neurons in two brainstem areas, the ventrolateral medulla and the rostral dorsolateral pons, in caffeine-treated rat pups, or more specifically, the parabrachial and Kölliker-Fuse nuclei, both of which are classically associated with respiratory control. With previous research highlighting the important role played by the rostral pons in respiratory modulation by the adenosine A1 receptor system, it is thus possible that postnatal exposure to caffeine modulates the ontogeny of the adenosine A1 receptor network. This could imply that the role of caffeine to decrease the incidence of neonatal respiratory disturbances may be due to the earlier than normal development of the adenosinergic system in the brain. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect